BCPT

(redirected from Breast Cancer Prevention Trial)
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BCPT

Breast Cancer Prevention Trial. A study of 13388 women at increased risk of breast cancer (BC): in women age 60+, < age 60 but at increased risk of BC, or with history of lobular carcinoma in situ, and randomised to receive tamoxifen or placebo.

Results
Tamoxifen reduces the risk of invasive BC by 49%; despite its side effects—e.g., increased risk of endometrial cancer, RR 2.53, stroke, pulmonary embolism and deep vein thrombosis—its use as a prophylaxis is appropriate in high-risk women.
References in periodicals archive ?
The initial results of the breast cancer prevention trial were released in 1998, showing a 45 percent reduction in breast cancer among the high-risk participants who took tamoxifen.
Status of antiestrogen breast cancer prevention trials.
The National Heart, Lung, and Blood Institute is contributing an additional $8 million to the Breast Cancer Prevention Trial in order to examine the effect of tamoxifen on the rate of cardiovascular disease.
Wickerham of the NSABP was an investigator and served as the protocol officer on the Breast Cancer Prevention Trial, which established the efficacy of tamoxifen for preventing invasive breast cancer in high-risk women.
NCI has temporarily halted recruitment of patients into the breast cancer prevention trial, which, like B-14, is run by NSABP.
With the same hypothetical cohort, and if it is assumed tamoxifen would result in a 49% reduction in the number of invasive breast cancers in high risk women as demonstrated in the 1998 placebo-controlled National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Cancer Prevention Trial, a maximum of only 6%8% of invasive cancers would be prevented (Arch.
The National Institutes of Health-sponsored Breast Cancer Prevention Trial demonstrated that the endometrial cancer rate was increased fourfold with tamoxifen chemoprevention therapy among women with an intact uterus in this age group, with much less risk in younger women, explained Dr.
In his defense, Fisher told the panel that NSABP had grown tremendously after it took on the Breast Cancer Prevention Trial, a large study in which women at risk of breast cancer are given the hormonal drug tamoxifen to ward off the disease.
For those who can benefit from chemoprevention with tamoxifen, the benefit is "real and impressive," he said, stressing that the findings of the University of North Carolina study don't contradict those of the Breast Cancer Prevention Trial.
The Gail model was validated in the Breast Cancer Prevention Trial of the National Surgical Adjuvant Breast and Bowel Project, sponsored by the National Cancer Institute.
The widely publicized Breast Cancer Prevention Trial showed that tamoxifen reduced the incidence of breast cancer for healthy women at high risk for the disease, but they were 2.
For example, this case has raised questions about the Breast Cancer Prevention Trial, a controversial study in which healthy women at high risk of developing breast cancer take the drug tamoxifen in hopes of staving off the disease (SN: 4/16/94, p.
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