were frequently nonsusceptible to azoles and echinocandins and were commonly associated with breakthrough infections
and high mortality rates.
"Despite breakthrough infection
still occurring, HBV-related complications such as cirrhosis and hepatocellular carcinoma in the next generation may be minimized as much as possible through a well-conducted surveillance and secondary preventive system with good antiviral therapies," they noted.
(24) Since 63% of infections were definite breakthrough infections
and the patients were severely ill we used combination therapy in most patients.
Despite the success of the adenovirus vaccine administered to US military trainees, acute respiratory disease (ARD) surveillance still detected breakthrough infections
(respiratory illnesses associated with the adenovirus serotypes specifically targeted by the vaccine).
Recombinant HBsAg that represents common mutants found in neonatal breakthrough infections
was tested with different immunoassay formats (Table 1).
A strong case exists for the implementation of a birth dose of hepatitis B vaccine in addition to the current schedule, as recommended by the WHO, to decrease the risk of perinatal transmission, prevent breakthrough infections
, and decrease HBsAg carriage in HIV-positive babies.
Asymptomatic infection characterized by the presence of anti-HBc in the absence of HBsAg viremia ("mild breakthrough infections
") have been documented in vaccinated individuals.
The increasing number of reports of sporadic breakthrough infections
in patients receiving echinocandin therapy is worrying, explained Dr.
(10) Data on posaconazole are emerging but breakthrough infections
in immunocompromised hosts have been reported.
In that population, breakthrough infections
occur in only about 0%-7% of individuals more than 20 years after vaccination, and most of those are asymptomatic.
Fifty-nine percent discontinued the therapy because IV access was no longer needed, 7% died from non IC-related causes, 2% transferred to other hospitals, 2% had breakthrough infections
, and 1% had transient elevation of liver transaminases, which resolved when FP was discontinued, Dr.