BCR

(redirected from Breakpoint Cluster Region)
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BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
References in periodicals archive ?
6] Human genes: ABL, ABLI, v-abl Abelson murine leukemia viral oncogene homolog 1; BCR, breakpoint cluster region.
The majority of chromosomal breaks occur in two regions: the major breakpoint cluster region (mbr), where 50-75% of the breaks occur, and the minor breakpoint cluster region (mcr), where 20-40% of the breaks occur [25, 26].
This 8 kb region is referred to as the MLL breakpoint cluster region (bcr).