Breakage Syndrome

Any molecular disease characterised by chromosomal breaks and rearrangements that increase risk of CA—e.g., Bloom and Fanconi syndromes, ataxia-telangiectasia, xeroderma pigmentosum
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Coverage includes the clinical features of AT, mutations in the AT mutated gene, cell signaling in AT, DNA damage and repair in AT, protein-protein interactions in AT, chromosomal instability in AT, cell cycle defects and apoptosis in AT, oxidative stress and AT, oncogenesis in AT, AT and its overlap with Nijmegen Breakage Syndrome and ataxia-like disorders, and animal models for AT.
Slovis said some children with hereditary diseases--including ataxiatelangiectasia, basal cell nevus syndrome, Cockayne's syndrome, Down syndrome, Fanconi's anemia, Gardner's syndrome, Nijmegen breakage syndrome, and Usher's syndrome--are extremely sensitive to radiation and should not be exposed at all, if possible.