BrDu


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BrDu

Abbreviation for bromodeoxyuridine.
Farlex Partner Medical Dictionary © Farlex 2012
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BrdU is a thymidine analog that can be incorporated into DNA during replication; therefore, BrdU is widely used for labeling proliferating cells (21).
Donor human prostates are collected, and epithelial cells place in primary culture (1[degrees] PrEC) with 1 [micro]M BrdU for 10 d.
Subsequently, cells were incubated with FITC labelled anti-BrdUMoAb (BD Pharmingen FITC BrdU Flow kit) for 45minutes.
For example, BrdU that is used to substitute thymidine residues in DNA and required for harlequin staining pattern of sister chromatids for analysis is known to be genotoxic and can result in slightly increased SCE frequency of around 1-3 per metaphase [28-30].
Using BrdU to label proliferative cells, we found the numbers of BrdU-positive cells in the ipsilateral SVZ and periinfarction of ischemic animals were higher than those in the sham group (Figures 2 and 3).
Such data did not support the antiproliferative and suppressive role of E2 in cell division indicated by reduced BrdU incorporation (Figure 1(b)) or KEGG pathway analysis (Table S1).
First, we assayed for slowly recycling cells in the limbal epithelium as evaluated by BrdU label retaining cells 8 days after pulse treatment with IP BrdU (Figure 1(a)).
These results were confirmed by cell cycle analysis and BrdU uptake showing higher percentage of proliferation in myofibroblasts isolated from [Thy1.sup.-]deficient mice (66%) compared to myofibroblasts isolated from WT mice (6%) (Figure 2(b)).
Tumor samples, obtained from patients, and/or tumorgrafts, collected from mice, were analyzed for proliferation, through Ki67 expression (Figure 4), BrdU incorporation (tumorgrafts only; Figure 5) and CDKN1B expression (p27 KIP1) (Figure 6) as well as for apoptosis, through BCL2 expression (Figure 7), in malignant cells.
They then biopsied the tissue to measure how many new olfactory basal stem cells were growing and dividing (healing), using BrdU as a marker of replicating DNA.
Detection of cell proliferation: An intraperitoneal injection of BrdU (50 mg/kg, Sigma-Aldrich) was administered 4.5 hr before the uterus was collected.