BRCA2

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BRCA2

A gene on chromosome 13q12.3 that encodes a protein which, like BRCA1, is involved in maintenance of genome stability, especially the homologous recombination pathway for double-stranded DNA repair; like BRCA1, it carries a marked increase in the lifetime risk of breast and ovarian cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

BRCA2

Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
BRCA2 protein also controls cell growing, and interacts with RAD51 in DNA repair and homologous recombination (10).
Moreover, four different deleterious mutations were identified in BRCA2 gene: the BRCA2 mutation c.7654dupA is predicted to result in the substitution of isoleucine for asparagine at amino acid position 2552 followed by a premature truncation of the BRCA2 protein at amino acid position 2553.
The BRCA2 protein is involved in repairing damaged DNA, playing a critical role in stabilising cells.
These observations have created a question: Why does the BRC4 peptide inhibit filament formation but the whole BRCA2 protein appears to promote filament formation?
BRCA2 protein acts as a mediator, helping another protein, RAD51, to associate with a single strand of DNA and stimulating its activity.
The BRCA1 and BRCA2 protein products are classified as tumour suppressor genes and are involved in DNA repair, genomic stability, transcriptional regulation and cell cycle control.
The specificity of the antibody was verified against the full-length (390 kDa) BRCA2 protein extracted from HeLa cell nuclear extract.
The research studied how the BRCA2 protein molecule interacts with Rad51 and how the process goes wrong when BRCA2 is faulty.
The functions of the BRCA2 protein appear similar to that of BRCA1, although BRCA2 tumours have different cellular expression.
"The PALB2 gene codes for proteins known to interact with BRCA1 and BRCA2 proteins. Together, they aid in DNA recombination and damage repair.
The mRNA is then translated to the BRCA1 and BRCA2 proteins, which become products of nature found within the cell.