concentrate and oral leukoplakia: a randomized phase IIb trial.
The Bowman-Birk Inhibitor
from soybeans as an anticarcinogenic agent.
In soybeans, two different protease inhibitors can be found--chymotrypsin, also called the Bowman-Birk inhibitor
(BBI), and trypsin, known as the Kunitz trypsin inhibitor (KTI) (STAHLHUT; HYMOWITZ, 1983; MANDARINO, 2010).
The Bowman-Birk inhibitor
, trypsin-and chymotrypsin-inhibitor from soybeans, Int.
Identification and characterization of a Bowman-Birk inhibitor
active towards trypsin but not chimotrypsin in Lupinus albus seeds.
Soybeans also contain a radioprotective enzyme inhibitor known as the Bowman-Birk inhibitor
Kunitz and Bowman-Birk are the two major types of trypsin inhibitors in soybeans (Rackis, 1972), but the Kunitz trypsin inhibitor is of particular interest because it is heat labile, whereas the Bowman-Birk inhibitor
exhibits a considerable resistance to heat treatment (Clemente et al.
soy, which, however aggressively it may be pushed as a beneficial food, contains one of the most potent natural trypsin inhibitors known, the Bowman-Birk Inhibitor
Scientists at Louisiana State University have demonstrated the in-vitro inhibitory activity of the Bowman-Birk inhibitor
from soybean and rice, ellagic acid from grapes, black bean tannins, thymoquinone from black seeds, purpurin, and phytic from cereals and legumes against angiogenesis stimulators such as the matrix metalloproteinase-1, -2, and -9, and cancer cell proliferation.
To protect the insulin released from the delivery system in the intestine before absorption, protease inhibitors like aprotinin, trypsin inhibitor, chymotrypsin inhibitors, Bowman-Birk inhibitor
, etc could be incorporated along with insulin in the delivery system.
The protective effect of soya is due to the isoflavones (the active constituents you can buy in supplement form) and the Bowman-Birk inhibitor
, which has been shown to prevent the onset of cancer in animals by 40-100%, depending on the type of cancer.
The agent, a concentrate of the soybean extract known as Bowman-Birk inhibitor
(BBI) will now be tested in a 6-month, randomized, blinded trial of 90 patients, said Dr.