aprotinin(redirected from Bovine pancreatic trypsin inhibitor)
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an inhibitor of proteolytic enzymes, used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
A polypeptide obtained from bovine lungs that is a protease inhibitor and has been used to reduce bleeding in patients undergoing cardiopulmonary bypass surgery. It was largely withdrawn from the market in 2007 because of safety concerns.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
aprotininA bovine polypeptide and protease inhibitor with antifibrinolytic activity that derives from basic pancreatic trypsin inhibitor (BPTI), which was added to fibrinogen in “fibrin glue”, theoretically enhancing the persistence of the fibrin clot.
It was pulled from the international market in 2007, given the concern that aprotinin increased the risk of complications and death during surgery. In 2012 the European Medicines Agency concluded that the benefits outweighed the risks, and recommended the suspension be lifted.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
aprotininA drug used in the treatment of bleeding resulting from the excessive breakdown of the fibrin that forms blood clots. An antifibrinolytic. A brand name is Trasylol. In September 2006 the FDA issued a warning that this drug could cause renal failure, congestive heart failure, stroke and death.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005