Borna disease

(redirected from Bornaviridae)
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Related to Bornaviridae: Coronaviridae, birnavirus, Mononegavirales

Borna disease

An infectious encephalopathy of warm-blooded animals, including ruminants (e.g., cattle, horses, sheep), foxes, dogs, cats, birds and primates, which occurs in Central Europe, caused by the Borna virus.
 
Clinical findings
Motor and behavioural symptoms—aggression, eating disorders, hyperactivity, postural disorders, ataxia, disrupted social and sexual activity.
 
Epidemiology
Uncertain, probably via saliva or nasal secretions.

Mortality
Up to 100% in horses, 50% in sheep.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The 4 exceptions comprise 2 families that have no known human-infective viruses (Arteriviridae and Birnaviridae) and 2 with species that have been reported in humans but only at level 2 (Asfarviridae and Bornaviridae).
Initially designated as ABV-CG due to the high prevalence in Canada geese, the virus has been renamed aquatic bird bornavirus 1 (ABBV-1) in a reorganization of the taxonomy of the Bornaviridae (4).
Taxonomic reorganization of the family Bornaviridae. Arch Virol.
Only recently has the cause of the disease been identified by characterization of a newly discovered member of the family Bornaviridae, the avian bornavirus (ABV), which has been detected in affected psittacines (3,4).
Recently, 2 independent groups of investigators identified a new member of the family Bornaviridae, named avian bornavirus (ABV), in parrots with histopathologically confirmed PDD.
(9) provided evidence that PDD is associated with the presence of novel virus species within the family Bornaviridae, provisionally termed avian bornavirus (ABV).
As the prototype and only known member of the family Bornaviridae in the order Mononegavirales (nonsegmented, negative-strand RNA viruses), BDV is atypical in its nuclear localization of transcription, alternative splicing, and differential use of initiation and termination signals.
Borna disease (BD) is a severe immunopathologic disorder of the central nervous system induced by infection with Borna disease virus (BDV), the prototype of a new virus family, Bornaviridae, within the order Mononegavirales.