Borna disease


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Borna disease

An infectious encephalopathy of warm-blooded animals, including ruminants (e.g., cattle, horses, sheep), foxes, dogs, cats, birds and primates, which occurs in Central Europe, caused by the Borna virus.
 
Clinical findings
Motor and behavioural symptoms—aggression, eating disorders, hyperactivity, postural disorders, ataxia, disrupted social and sexual activity.
 
Epidemiology
Uncertain, probably via saliva or nasal secretions.

Mortality
Up to 100% in horses, 50% in sheep.
References in periodicals archive ?
Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation.
It has been recognised that Borna disease virus (BDV) could cause neuropsychiatric complications including neurological, behavioural, and mood alterations in animals.
Persistent Borna disease virus infection of neonatal rats causes brain regional changes of mRNAs for cytokines, cytokine receptor components and neuropeptides Brain Res Bull 1999; 49; 441-451.
The family Bornaviridae comprises the classical mammalian bornaviruses (Mammalian 1 bornavirus with borna disease virus; BoDV-1 and -2); avian bornaviruses (Passeriform 1/2 bornavirus, Psittaciform 1/2 bornavirus, Waterbird 1 bornavirus); and a recently described Elapid 1 bornavirus from snakes (Loveridge's garter snake virus 1) (1).
To the Editor: Borna disease (BD) is a fatal neurologic disorder in horses and sheep.
Antibodies against ABV were detected by use of an IIFA on persistently Borna disease virus (BDV)-infected Madin-Darby canine kidney cells.
Before this discovery, the family Bornaviridae contained only 1 species, Borna disease virus (BDV).
Borna disease virus was named after the town of Borna in Saxony, southeastern Germany, where in 1885 many horses in a German cavalry regiment died of a fatal neurologic disease.
Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus.
Borna disease virus (BDV) is the causative agent of Borna disease, a meningoencephalitis of horses and sheep in central Europe (1).