hitting the wall

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The depletion of glycogen stores in the liver and muscles, which manifests itself by abrupt fatigue and loss of energy
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

hit·ting the wall

(hit'ing wawl)
A term athletes use to describe an abrupt decline in the ability to maintain the desired intensity of endurance exercise performance; associated with accumulation of blood lactate and depletion of liver and muscle glycogen reserves.
See also: fatigue
Medical Dictionary for the Health Professions and Nursing © Farlex 2012