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Related to Bonine: meclizine


trademark for preparations of meclizine, an antinauseant.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

meclizine hydrochloride (meclozine (UK))

Antivert, Bonamine (CA), Bonine, Dramamine Less Drowsy Formula, Sea-Legs (UK), Traveleeze (UK)

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo drug

Pregnancy risk category B


Decreases excitability of middle-ear labyrinth and depresses conduction in vestibular-cerebellar pathways


Tablets: 12.5 mg, 25 mg, 50 mg

Tablets (chewable): 25 mg

Indications and dosages

Motion sickness

Adults: 25 to 50 mg P.O. 1 hour before travel. May repeat q 24 hours for duration of travel.

Vertigo associated with diseases affecting the vestibular system

Adults: 25 to 100 mg P.O. daily in divided doses


• Hypersensitivity to drug


Use cautiously in:

• prostatic hypertrophy, stenosing peptic ulcer, bladder neck obstruction, pyloroduodenal obstruction, arrhythmias, angle-closure glaucoma, bronchial asthma

• pregnant or breastfeeding patients

• children (younger than age 12).


• Know that tablets may be chewed or swallowed whole.

Adverse reactions

CNS: drowsiness, fatigue, confusion, excitement, euphoria, nervousness, restlessness, insomnia, vertigo, visual and auditory hallucinations, seizures

CV: hypotension, palpitations, tachycardia

EENT: blurred vision, diplopia, tinnitus, dry nose, dry throat

GI: nausea, vomiting, diarrhea, constipation, dry mouth, anorexia

GU: difficulty urinating, urinary retention, urinary frequency

Skin: rash, urticaria


Drug-drug. Anticholinergics (including some antihistamines, antidepressants, atropine, haloperidol, phenothiazines): additive anticholinergic effects

Antihistamines, CNS depressants (such as opioids, sedative-hypnotics): additive CNS depression

Drug-diagnostic tests. Skin tests using allergen extracts: false-negative results

Drug-behaviors. Alcohol use: additive CNS depression

Patient monitoring

• Discontinue drug, as ordered, at least 4 days before skin testing.

• Know that drug has anticholinergic effects.

Patient teaching

• Tell patient to take as prescribed to minimize adverse effects.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Advise patient to relieve dry mouth with hard candy or frequent sips of fluids.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug meclizine hydrochloride.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
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Jeanne Bonine, an artist from Scottsdale, AZ, had this to say, "All of my expectations were met at the Atlanta Expo thanks to the wonderful and caring staff that took time to make everything work.
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(7) For details, see Farhad Kazemi and Lisa Reynolds Wolfe, "Urbanization, Migration, and Politics in Iran," in Population, Poverty, and Politics in Middle Eastern Cities, Michael Bonine, ed.
What better preparation for lying on a bunk deep in Seahound's bow, white knuckles gripping something, anything, desperate for sleep (the Bonine is working, but the earplugs are at home), praying, "Please, let us get there." Commercial fishing is no day at the beach; in Seahound's case, it's often 30 miles from one, but captain and mate have adapted long before this day.