Bonine


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Related to Bonine: meclizine

Bonine

 [bo´nēn]
trademark for preparations of meclizine, an antinauseant.

meclizine hydrochloride (meclozine (UK))

Antivert, Bonamine (CA), Bonine, Dramamine Less Drowsy Formula, Sea-Legs (UK), Traveleeze (UK)

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo drug

Pregnancy risk category B

Action

Decreases excitability of middle-ear labyrinth and depresses conduction in vestibular-cerebellar pathways

Availability

Tablets: 12.5 mg, 25 mg, 50 mg

Tablets (chewable): 25 mg

Indications and dosages

Motion sickness

Adults: 25 to 50 mg P.O. 1 hour before travel. May repeat q 24 hours for duration of travel.

Vertigo associated with diseases affecting the vestibular system

Adults: 25 to 100 mg P.O. daily in divided doses

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• prostatic hypertrophy, stenosing peptic ulcer, bladder neck obstruction, pyloroduodenal obstruction, arrhythmias, angle-closure glaucoma, bronchial asthma
• pregnant or breastfeeding patients
• children (younger than age 12).

Administration

• Know that tablets may be chewed or swallowed whole.

Adverse reactions

CNS: drowsiness, fatigue, confusion, excitement, euphoria, nervousness, restlessness, insomnia, vertigo, visual and auditory hallucinations, seizures

CV: hypotension, palpitations, tachycardia

EENT: blurred vision, diplopia, tinnitus, dry nose, dry throat

GI: nausea, vomiting, diarrhea, constipation, dry mouth, anorexia

GU: difficulty urinating, urinary retention, urinary frequency

Skin: rash, urticaria

Interactions

Drug-drug.Anticholinergics (including some antihistamines, antidepressants, atropine, haloperidol, phenothiazines): additive anticholinergic effects

Antihistamines, CNS depressants (such as opioids, sedative-hypnotics): additive CNS depression

Drug-diagnostic tests.Skin tests using allergen extracts: false-negative results

Drug-behaviors.Alcohol use: additive CNS depression

Patient monitoring

• Discontinue drug, as ordered, at least 4 days before skin testing.
• Know that drug has anticholinergic effects.

Patient teaching

• Tell patient to take as prescribed to minimize adverse effects.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Advise patient to relieve dry mouth with hard candy or frequent sips of fluids.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

Bonine

(bō′nēn′)
A trademark for the drug meclizine hydrochloride.

Bonine

a trademark for an antiemetic (meclizine hydrochloride).
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UO law professor John Bonine said Wednesday that UO lawyers - and lawyers elsewhere - tend to put that on everything they write.
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Law Professor John Bonine concluded that the resolution would not only get rid of nuisance parking regulations but supersede the university's charter, constitution and the foundation of the faculty's authority over academics.
Workflow and Forms Routing in SharePoint 2007 Using SharePoint Designer and InfoPath," Roger Bonine, Baker & McKenzie Global Services LLC * 11 a.
Today's over-the-counter drugs are a big step forward: Dramamine (dimenhydrinate), Bonine and Dramamine II (meclizine), the antihistamine Benadryl (diphenhydramine) and Peptobismal have all been used to varying degrees of success.