Bonine


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Related to Bonine: meclizine

Bonine

 [bo´nēn]
trademark for preparations of meclizine, an antinauseant.

meclizine hydrochloride (meclozine (UK))

Antivert, Bonamine (CA), Bonine, Dramamine Less Drowsy Formula, Sea-Legs (UK), Traveleeze (UK)

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo drug

Pregnancy risk category B

Action

Decreases excitability of middle-ear labyrinth and depresses conduction in vestibular-cerebellar pathways

Availability

Tablets: 12.5 mg, 25 mg, 50 mg

Tablets (chewable): 25 mg

Indications and dosages

Motion sickness

Adults: 25 to 50 mg P.O. 1 hour before travel. May repeat q 24 hours for duration of travel.

Vertigo associated with diseases affecting the vestibular system

Adults: 25 to 100 mg P.O. daily in divided doses

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• prostatic hypertrophy, stenosing peptic ulcer, bladder neck obstruction, pyloroduodenal obstruction, arrhythmias, angle-closure glaucoma, bronchial asthma

• pregnant or breastfeeding patients

• children (younger than age 12).

Administration

• Know that tablets may be chewed or swallowed whole.

Adverse reactions

CNS: drowsiness, fatigue, confusion, excitement, euphoria, nervousness, restlessness, insomnia, vertigo, visual and auditory hallucinations, seizures

CV: hypotension, palpitations, tachycardia

EENT: blurred vision, diplopia, tinnitus, dry nose, dry throat

GI: nausea, vomiting, diarrhea, constipation, dry mouth, anorexia

GU: difficulty urinating, urinary retention, urinary frequency

Skin: rash, urticaria

Interactions

Drug-drug. Anticholinergics (including some antihistamines, antidepressants, atropine, haloperidol, phenothiazines): additive anticholinergic effects

Antihistamines, CNS depressants (such as opioids, sedative-hypnotics): additive CNS depression

Drug-diagnostic tests. Skin tests using allergen extracts: false-negative results

Drug-behaviors. Alcohol use: additive CNS depression

Patient monitoring

• Discontinue drug, as ordered, at least 4 days before skin testing.

• Know that drug has anticholinergic effects.

Patient teaching

• Tell patient to take as prescribed to minimize adverse effects.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Advise patient to relieve dry mouth with hard candy or frequent sips of fluids.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

Bonine

(bō′nēn′)
A trademark for the drug meclizine hydrochloride.
References in periodicals archive ?
Alvarado se entero de esta situacion al saber de una solicitud de una manzana de terreno hecha por Bonine, por lo que este le ofrecio la renta de un convento catolico confiscado para que la escuela protestante lo ocupase.
the late Professor Kravchenko and John Bonine note, "[i]n addition
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Noting the increasing recognition around the world of substantive and procedural environmental rights as enforceable human rights, Kravchenko and Bonine (both of the U.
As frutas citricas sao destinadas preponderantemente ao consumo de mesa, sendo suas culturas fundamentadas em pequenos pomares, com area media de 2 a 3 hectares, e de exploracao familiar, exercendo importante papel na geracao de empregos e na fixacao do homem no campo (BONINE & JOAO, 2002).
Over-the-counter antihistamines, such as meclizine (Antivert, Bonine), dimenhydrinate (Dramamine), and diphenhydramine (Benadryl) are commonly used for prevention.
Jeanne Bonine, an artist from Scottsdale, AZ, had this to say, "All of my expectations were met at the Atlanta Expo thanks to the wonderful and caring staff that took time to make everything work.
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(7) For details, see Farhad Kazemi and Lisa Reynolds Wolfe, "Urbanization, Migration, and Politics in Iran," in Population, Poverty, and Politics in Middle Eastern Cities, Michael Bonine, ed.
What better preparation for lying on a bunk deep in Seahound's bow, white knuckles gripping something, anything, desperate for sleep (the Bonine is working, but the earplugs are at home), praying, "Please, let us get there." Commercial fishing is no day at the beach; in Seahound's case, it's often 30 miles from one, but captain and mate have adapted long before this day.