(8.) De Castro, F.C., Cruz, M.H.C., Leal, C.L.V., Role of growth differentiation factor 9 and bone morphogenetic protein 15
in ovarian function and their importance in mammalian female fertility - A review.
In addition, numerous studies have revealed that bone morphogenetic protein 15
(BMP15) is differentially expressed in small and large antral follicles during the development in vitro of cultured preantral follicles (Pramod et al., 2013; Lima et al., 2012).
Two related members of the TGFB superfamily are involved in the function and development of the ovary: Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15
Growth differentiation factor 9 and bone morphogenetic protein 15
(BMP15) are two oocyte-specific proteins and co-expressed by growing oocytes in rodents, sheep, and humans (1-3).
The bone morphogenetic protein 15
gene is X-linked and expressed in oocytes.
Differential gene expression of bone morphogenetic protein 15
and growth differentiation factor 9 during in vitro maturation of porcine oocytes and early embryos.
Cloning of Rabbit Bone Morphogenetic Protein 15
and Its Expression During in vitro Maturation of Rabbit Oocytes.
A new candidate gene, bone morphogenetic protein 15
(BMP15) has been investigated in POF.
Key Words: Bone morphogenetic protein 15
, BMP15, polymorphisim, nucleotide aligment.
By promoting granulosa cell mitosis, bone morphogenetic protein 15
inhibits the expression of the follicle-stimulating hormone receptor in granular cells, and adjusts their proliferation and differentiation.
In sheep, three prolificacy loci have been discovered, namely bone morphogenetic protein receptor type 1B (BMPR1B; or activin-like kinase 6, ALK6), known as FecB (Booroola) on chromosome 6 (Souza et al., 2001) corresponding to the human chromosome 4q22-23 (Montgomery et al., 1993); growth differentiation factor 9 (GDF9), known as FecG on chromosome 5 (Hanrahan et al., 2004); and bone morphogenetic protein 15
(BMP15) known as FecX on chromosome X (Hanrahan et al., 2004; Galloway et al., 2000).