(8.) De Castro, F.C., Cruz, M.H.C., Leal, C.L.V., Role of growth differentiation factor 9 and bone morphogenetic protein 15 in ovarian function and their importance in mammalian female fertility - A review.
In addition, numerous studies have revealed that bone morphogenetic protein 15 (BMP15) is differentially expressed in small and large antral follicles during the development in vitro of cultured preantral follicles (Pramod et al., 2013; Lima et al., 2012).
By promoting granulosa cell mitosis, bone morphogenetic protein 15 inhibits the expression of the follicle-stimulating hormone receptor in granular cells, and adjusts their proliferation and differentiation.
In sheep, three prolificacy loci have been discovered, namely bone morphogenetic protein receptor type 1B (BMPR1B; or activin-like kinase 6, ALK6), known as FecB (Booroola) on chromosome 6 (Souza et al., 2001) corresponding to the human chromosome 4q22-23 (Montgomery et al., 1993); growth differentiation factor 9 (GDF9), known as FecG on chromosome 5 (Hanrahan et al., 2004); and bone morphogenetic protein 15 (BMP15) known as FecX on chromosome X (Hanrahan et al., 2004; Galloway et al., 2000).