However, because the height standard deviation score for bone age is a predictor of final height, the rapid bone maturation observed appears to offset gains in height for age.
"We conclude that short-term, highdose GH treatment during prepuberty results in significant improvement in height [standard deviation score], but an unexpected high rate of bone maturation and an early onset of puberty were observed.
In cases with PJS who develop LCCSCT, elevated aromatase activity not only causes gynecomastia but also leads to other undesired effects such as increased rates of linear growth and bone maturation
These differences were found only at the initial stages of bone maturation, as observed in the male group at stages CS2 and CS3, and in the female group at stage CS3.
Even though the present data are cross-sectional, they represent the first attempt to investigate possible gender differences of mandibular sizes in Class I and Class II subjects, within the same stage of bone maturation. Our results indicate that boys with the Class I pattern had greater mandibles than girls at stages CS2, CS4 and CS5, whereas in the Class II pattern the boys had greater mandibles than girls at stages CS2, CS3 and CS4.
* Subjects with skeletal Class I and Class II patterns had different mandibular lengths at the earlier stages of bone maturation.
How far along in bone maturation is any one girl at age 12?
If neither chronological age nor bone maturation alone determines when to begin pointe work, what other factors must be considered?
Similar studies in diabetic rats have shown significantly reduced growth in most mandibles compared to controls, with delays in bone maturation also shown in the foetuses of diabetic rats [Verhaeghe et al., 1999; Giglio and Lama, 2001].
A recent study utilizing an in vitro bone nodule formation assay, demonstrated that elevated glucose concentration inhibited osteoblastic calcium deposition and bone maturation [Balint et al., 2001].
The close follow-up during GH replacement, which was started one year before the onset of puberty, permitted a detailed recording of the genital and pubic hair development, pubertal growth spurt, and bone maturation. Besides a delayed pubertal surge in testosterone, a delayed increase in dehydroepiandrosterone sulfate (DHEAS) was documented in our patient.
The low DHEAS production might contribute to the delayed pubic hair growth, but also to the delayed bone maturation, which was observed before as well as during GH therapy.