bone marrow biopsy

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Related to bone marrow biopsy: bone marrow transplant, Bone marrow cancer

bone marrow biopsy

a microscopic tissue examination used to help evaluate patients with hematologic diseases. The biopsy may be done to confirm a diagnosis of megaloblastic anemia, to diagnose leukemia or myeloma, to determine the cause of reduced red blood cells in the peripheral bloodstream, to document deficient iron stores, to document bone marrow infiltrative diseases such as neoplasm or fibrosis, to identify tumors, and to diagnose a variety of other conditions.

bone marrow biopsy

(1) The insertion of a large-bore needle with a removable stylet into the iliac crest or sternum, to aspirate a sample of bone and bone marrow.

Evaluation of the marrow for leukaemia, multiple myeloma, lymphoma, anaemia and pancytopaenia.

(2) Commonly, the term bone marrow biopsy also refers (incorrectly) to the bone marrow examination itself.

bone mar·row bi·op·sy

(bōn marō bīop-sē)
Process whereby bone marrow is aspirated with a needle or trocar for microscopic examination.

bone marrow biopsy

A sample of marrow usually taken from the crest of the pelvis at the back under local anaesthesia using a broad stout needle attached to a syringe. Marrow biopsies allow diagnoses of the various forms of ANAEMIA, of failure of red cell production (aplastic anaemia), of reduced white cell production (AGRANULOCYTOSIS) and of the various kinds of white cell cancer (LEUKAEMIA).

Bone marrow biopsy

A procedure in which cellular material is removed from the pelvis or breastbone and examined under a microscope to look for the presence of abnormal blood cells characteristic of specific forms of leukemia and lymphoma.
Mentioned in: MALT Lymphoma


removal and examination, usually microscopic, of tissue from the living body. Biopsies are usually done to determine whether a tumor is malignant or benign; however, a biopsy may be a useful diagnostic aid in other disease processes such as infections.

aspiration biopsy
biopsy in which tissue is obtained by application of suction through a needle attached to a syringe.
bite biopsy
instrumental removal of a fragment of tissue.
bone marrow biopsy
obtaining a sample of bone marrow, usually by needle aspiration, from a long bone, rib or sternum, for cytological examination.
Enlarge picture
Needle aspiration of bone marrow. By permission from Ettinger SJ, Feldman E, Textbook of Veterinary Internal Medicine, Saunders, 2004
brush biopsy
removal of cells and tissue fragments using a brush with stiff bristles (introduced through an endoscope). Effective in obtaining tissue samples from inaccessible places such as the renal pelvis.
closed biopsy
one carried out without access through an open incision such as a laparotomy. An example is a percutaneous, fine needle aspirate.
cone biopsy
biopsy in which an inverted cone of tissue is excised, as from the uterine cervix.
cytological biopsy
obtaining specimens of cells by various methods including irrigation of a hollow tube.
biopsy dart
an alternative to immobilization of large and wild animals; a dart which cuts a skin bipsy, then falls out. Limited to use for superficial lesions.
endoscopic biopsy
removal of tissue by appropriate instruments through an endoscope.
excisional biopsy
biopsy of tissue removed from the body by surgical cutting.
exploratory biopsy
a combination of exploratory surgery to determine size and location of a lesion and the taking of a biopsy.
fine needle biopsy
see needle biopsy (below).
hepatic biopsy
may be by transperitoneal incision, more commonly by percutaneous needle or trocar and cannula technique.
incisional biopsy
biopsy of a selected portion of a lesion.
needle biopsy
biopsy in which tissue is obtained by puncture of a tumor, the tissue within the lumen of the needle being detached by rotation, and the needle withdrawn.
punch biopsy
see punch biopsy.
Robson-Heggers biopsy
a procedure for the collection of a piece of tissue from an infected wound in order to determine the extent and the nature of the infection.
sternal biopsy
biopsy of bone marrow of the sternum removed by puncture or trephining (see also sternal puncture).
surface biopsy
sample of cells scraped from the surface of a lesion or obtained by impression smears.
surgical biopsy
one obtained during a surgical procedure.
synovial biopsy
by a needle biopsy technique or through an arthrotomy incision using special forceps for a bite biopsy.
total biopsy
obtained by removal of the entire lesion. May be for therapeutic as well as diagnostic purposes.
ultrasound-guided biopsy
use of ultrasonography to guide the passage of a needle or biopsy instrument into an internal organ or lesion.
References in periodicals archive ?
Here we directly compared ferritin and sTfR in ill patients with independent documentation of iron status by bone marrow biopsy or response to iron therapy.
Comparative utility of bone marrow aspiration and bone marrow biopsy.
Trepanning or trephines: a history of bone marrow biopsy.
Bone marrow biopsy revealed trophozoites and ring forms of falciparum.
Findings on bone marrow biopsy and on radiographic and nuclear medicine bone surveys were unremarkable.
Because of persistent thrombocytopenia, a second bone marrow biopsy was performed in February 2002.
Package 7 Needles for bone marrow biopsy needle to puncture the sternum, needle biopsy
Bearden JD, Ratkin GA, Coltman CA, Comparison of the diagnostic value of bone marrow biopsy and bone marrow aspirate in neoplastic disease.