Blue Cell Tumour

A usually malignant tumour, the cells of which are arranged in nests, sheets, and masses, and composed of relatively monotonous, round-to-oval, 8–15-µm in diameter cells with poorly defined cytoplasmic borders and strongly basophilic—blue—by H&E staining nuclei; embryologic origin often requires ancillary information provided by histologic pattern, immunohistochemistry, and rarely electron microscopy
DiffDx
Children Neuroblastoma, Ewing sarcoma, NHL, embryonal rhabdomyosarcoma
Adults Neuroendocrine tumour, mesenchymal chondrosarcoma, hemangiopericytoma, large cell lymphomas, Merkel cell tumour, small cell osteosarcoma, small/oat cell carcinoma, alveolar rhabdomyosarcoma
References in periodicals archive ?
Metastasis from small round blue cell tumour was found in one patient in our study.
Number Percentage of Cases (%) Megaloblastic anaemia 36 63 Combined nutritional 9 16 anaemia Acute leukaemias 6 11 Myeloproliferative 2 4 disorders- Myelofibrosis Plasma cell 2 4 dyscrasias-Multiple myeloma Metastasis from small 1 2 round blue cell tumour Malaria 1 2 Table 3.
Diagnosed cases of neuroblastoma on hematoxylin and eosin stain along with immunohistochemistry for round blue cell tumour panel using Synaptophysin, Neuron specific Enolase, Desmin, Myogenin, CD45 and WT1 and referred for marrow biopsy from January 2016 to December 2017 were selected for this study.
Ewing sarcoma/peripheral primitive neuroectodermal tumour (EWS/PNET) is a malignant small round blue cell tumour. It is the second most common bone tumour in children and adolescents.
Histopathological examination of specimens obtained during tumour resection revealed poorly differentiated malignant neoplasm with papillary features and small, round, blue cell tumour morphology.
Microscopy revealed a highly necrotic and malignant small blue cell tumour. Homer Wright-like rosettes were present with high mitotic activity evident.
Poorly differentiated synovial sarcoma can have the morphologic appearance of a "small round blue cell tumour" and overlapping cytologic features with PNET.
Epithelial small round blue cell tumour in this location is usually the poorly differentiated non-keratinising squamous cell carcinoma involving the maxillary sinus followed by nasal cavity.
On histological examination post-graduate residents diagnosed the tumour as a round blue cell tumour consistent with the diagnosis of Wilms' Tumour.
Conclusion: The ONB has great variability of histological and clinical presentation, and immunohistochemical markers are useful to differentiate from more common small round blue cell tumours of nasal cavity.
Poorly differentiated synovial sarcoma is composed of uniform densely packed, small ovoid blue cells that resemble other small round blue cell tumours. In pure form, poorly differentiated synovial sarcomas rarely occur, however upto 20% cases of synovial sarcomas may contain poorly differentiated areas.
Other important uses of immunohistochemistry include determination of unknown primary tumours6 diagnosis of central nervous system tumours, diagnosis of Paediatric small round blue cell tumours, carcinomas, Melanoma and sarcomas.7-10