CLEC4C

(redirected from Blood dendritic cell antigen 2)

CLEC4C

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain protein involved in antigen capture, targeting ligands to peptide-loading compartments for presentation to T-cells. CLEC4C may downregulate IFN-alpha/beta expression in plasmacytoid dendritic cells; it may also act as a signalling receptor, activating protein-tyrosine kinases and mobilising intracellular calcium.
References in periodicals archive ?
They also express CD303 (blood dendritic cell antigen 2, BDCA2), cutaneous lymphocyte-associated antigen (CLA), granzyme B, and TCL1.
In addition, markers recently developed for PDCs, including CD123 (the interleukin-3 receptor), blood dendritic cell antigen 2 (BDCA2/CD303), (5) and T-cell leukemia/lymphoma 1 (TCL1) and CD2-associated protein (CD2AP), (6) were rarely tested in the literature published prior to 2008.
BPDCN; BDCA2/ CD303, blood dendritic cell antigen 2; TCL1, T-cell leukemia/lymphoma 1; CD2AP CD2-associated protein; CLA, cutaneous lymphocyte antigen; BCL11A, B-cell lymphoma/leukemia 11A; MPO, myeloperoxidase; TdT, terminal deoxynucleotidyl transferase; EBER, EBV-encoded nuclear RNA.