Blister Cell

An erythrocyte—RBC—containing one or 2 sharply defined, usually submembranous vacuoles
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Special sensors analyze the swelling of each blister cell when applied under vacuum and will reject faulty leaking blister packs accordingly.
"If they have to put a bar code on the blister cell, there won't be enough room for the other information the FDA requires them to put there."
There is less real estate on some of those containers than on a blister cell. In addition, some of the containers have a curved surface which can impact the readability of an RSS/CC code.
Again, though, the language of the rule is a little uncertain with regard to whether individual blister cells need bar codes, which is a big issue, of course, given their lack of packaging "real estate." The final rule states: "Regarding unit-of-use packages, the rule does require bar codes on such packages because Sec.
Pfizer is using RSS/CC codes-complete with NDC and lot number and expiration date--on its blister cells, which are packaged at three Pfizer locations in Puerto Rico, one in Brooklyn, N.Y.
On peripheral blood smear numerous blister cells were seen (Figure).
The only way to diagnose during an acute episode is to analyze peripheral blood smears for blister cells. Blister cells are the precursors of bite cells, which appear as red blood cells containing a peripherally located vacuole.
1) showed a leukoerythroblastic picture with marked polychromasia, large number of circulating nucleated red blood cells and marked poikilocytosis including blister cells, spherocytes and echinocytes, consistent with oxidative hemolysis.
Section II discusses the specifics of grading individual red blood cell abnormalities and defines a grading system described in words and images for anisocytosis, poikilocytosis, microcytosis, macrocytosis, hypochromia, polychromasia, blister cells, target cells, teardrop cells, schistocytes, sickle cells, spherocytes, acanthocytes, echinocytes, elliptocytes, stomatocytes, Howell-Jolly bodies, basophilic stippling, Pappenheimer bodies, rouleaux, and agglutination.
Hb (g/L) MCV (fL) MCH (pg) RDW Patient 1 113 72 24 Patient 2 94 56 17.4 25.7 Patient 3 101 63 20.4 20.7 Patient 4 87 57 18.3 21 Patient 5 127 67 20.7 18.3 Patient 6 107 65 21.1 16.7 Patient 7 89 65 21.3 16.3 Film comment Hb F (%) Comment Patient 1 8 Patient 2 poikilocytosis 9.6 anisocytosis target cells spherocytes fragments NRBC Patient 3 target cells 15 24 month spherocytes old, G6PD polychromasia deficient blister cells Patient 4 9 11 month old Patient 5 5.7 Patient 6 target cells 4.8 polychromasia spherocytes Patient 7 5 pregnant
Reticulocytosis is marked and peripheral film typically shows sphercoytes, polychromasia, bite and blister cells. Indirect bilirubin and LDH are elevated as in any acute haemolysis.