The exclusion criteria included (i) any intestinal tract perforations, (ii) any acute intestinal infection disease (e.g., ulcerative colitis or Crohn's disease), (iii) severe internal hemorrhoid or crissum varicosity bleeding, and (iv) severe bleeding tendency
or coagulation disorders.
Acid suppression therapy is a key part of ICU bundle in patients receiving mechanical ventilation for greater than 48 hours and patients having any bleeding tendency
such as coagulopathy or thrombocytopenia1.
There is no linear relationship between factor levels and bleeding tendency
and incidence of spontaneous bleeding (4).
Paris-Trousseau thrombocytopenia is a disorder that presents with mild bleeding tendency
with variable thrombocytopenia, abnormal giant alpha-granules in platelets, and dysmegakaryopoiesis.
The Phase I data were analyzed to identify participants who gave a positive response to any of the primary questions; these participants were considered to potentially have a bleeding tendency
In general, the bleeding tendency
in GT decreases with age.
Most frequent clinical features at presentation included fever 266(71.9%), weakness 168(45.4%) and bleeding tendency
 Characteristic clinical presentation of haemophilia is bleeding tendency
. In severe haemophilia bleeding is spontaneous, whereas in moderate, prolonged bleeding with minor trauma and in mild bleeding occurs with major trauma or surgery.
Among 276 patients who met the inclusion criteria for participation in the current study, 226 were excluded because of successful bleeding control with cold saline, cardiovascular disease, bleeding tendency
, or anticoagulant and antiplatelet drug consumption.
Other factors such as kidney and liver disease, history of bleeding tendency
, anemia and use of drugs and alcohol also contribute.
The risk factors for rebleeding in MWTs have been reported to be bleeding tendency
and/or low hemoglobin level [4, 6].
Interestingly, one may postulate that the low FVIII in our patient of 17% is in favor of bleeding tendency
; however, the occurrence of DVT in the setting of low systemic level of FVIII may suggest the strong hypercoagulability potential of heterozygous prothrombin G20210A mutation or, on the other hand, might suggest the hypothesis of FVIII administration as a predisposing factor for local thromboembolism development in hemophilia A patients.