blast crisis

(redirected from Blast Phase)

crisis

 [kri´sis] (pl. cri´ses) (L.)
1. the turning point of a disease for better or worse; especially a sudden change, usually for the better, in the course of an acute disease.
2. a sudden paroxysmal intensification of symptoms in the course of a disease.
addisonian crisis (adrenal crisis) the symptoms accompanying an acute onset or worsening of addison's disease: anorexia, vomiting, abdominal pain, apathy, confusion, extreme weakness, and hypotension; if untreated these progress to shock and then death.
aplastic crisis a sickle cell crisis in which there is temporary bone marrow aplasia.
blast crisis a sudden, severe change in the course of chronic granulocytic leukemia, characterized by an increased number of blasts, i.e., myeloblasts or lymphoblasts.
catathymic crisis an isolated, nonrepetitive act of violence that develops as a result of intolerable tension.
celiac crisis an attack of severe watery diarrhea and vomiting producing dehydration and acidosis, sometimes occurring in infants with celiac disease.
developmental crisis maturational crisis.
hemolytic crisis an uncommon sickle cell crisis in which there is acute red blood cell destruction with jaundice.
hypertensive crisis dangerously high blood pressure of acute onset.
identity crisis a period in the psychosocial development of an individual, usually occurring during adolescence, manifested by a loss of the sense of the sameness and historical continuity of one's self, confusion over values, or an inability to accept the role the individual perceives as being expected by society.
life crisis a period of disorganization that occurs when a person meets an obstacle to an important life goal, such as the sudden death of a family member, a difficult family conflict, an incident of domestic violence (spouse or child abuse), a serious accident, loss of a limb, loss of a job, or rape or attempted rape.
maturational crisis a life crisis in which usual coping mechanisms are inadequate in dealing with a stress common to a particular stage in the life cycle or with stress caused by a transition from one stage to another. Called also developmental crisis.
myasthenic crisis the sudden development of dyspnea requiring respiratory support in myasthenia gravis; the crisis is usually transient, lasting several days, and accompanied by fever.
oculogyric crisis a symptom of an acute dystonic reaction in which the person demonstrates a fixed gaze, usually upward; also, the uncontrollable rolling upwards of the eye. It can be a result of encephalitis or a reaction to antipsychotic medications.
salt-losing crisis see salt-losing crisis.
sickle cell crisis see sickle cell crisis.
tabetic crisis a painful paroxysm occurring in tabes dorsalis.
thyroid crisis (thyrotoxic crisis) see thyroid crisis.
vaso-occlusive crisis a sickle cell crisis in which there is severe pain due to infarctions in the bones, joints, lungs, liver, spleen, kidney, eye, or central nervous system.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

blast cri·sis

a sudden alteration in the status of a patient with leukemia in which the peripheral blood cells are almost exclusively blast cells of the type characteristic of leukemia; usually accompanied by a decrease in numbers of other formed elements of the blood, fever, and rapid clinical deterioration.
Farlex Partner Medical Dictionary © Farlex 2012
The abrupt conversion of a chronic, relatively indolent leukemia, usually CML, into an acute decompensated, accelerated phase, with a marked—30+% of WBCs—increased proportion of blasts and number of lymphocytes or myelocytes in circulation and bone marrow
Lab Leukocytosis, thrombocytosis or thrombocytopenia, anemia
Management Response to blast crises is usually short-lived; myeloblast transformations are commonly treated with hydroxyurea; one-fourth respond to prednisone with vincristine
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

blast crisis

Blast phase, blast transformation Oncology The abrupt conversion of a chronic, relatively indolent leukemia usually CML into an acute decompensated, accelerated phase, with a marked–30+% of WBCs—↑ proportion of blasts and number of lymphocytes or myelocytes in circulation and BM Clinical Lymphadenopathy, hepatosplenomegaly, spleen and bone pain, fever, thrombosis Lab Leukocytosis, thrombocytosis or thrombocytopenia, anemia Management Response to BCs is usually short-lived; myeloblast transformations are commonly treated with hydroxyurea;14 respond to prednisone with vincristine. Cf Blast transformation, Relapse.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Blast crisis

Stage of chronic myelogenous leukemia where large quantities of immature cells are produced by the marrow and is not responsive to treatment.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
AML consolidation also remains an important indication in our BL-8040 development plan, and we, with our partners, continue to progress our BLAST Phase 2b study towards a robust interim analysis.
Chronic Myelogenous Leukemia (CML) usually presents in chronic phase, followed by an accelerated phase and a blast phase, if untreated.
Bosulif was first approved in September 2012 in the US for the treatment of adult patients with chronic, accelerated or blast phase Ph+ CML with resistance or intolerance to prior therapy.
Patients diagnosed with accelerated and blast phase of CML has a bad response while treatment only using TKIs.
As per definition, CML blast phase can be diagnosed if an extramedullary blast proliferation is identified (i.e., myeloid sarcoma or chloroma).
Goh et al., "Dasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily," Cancer, vol.
Professor Mark Drakeford said: "I'm pleased to announce we will be making this medicine available to adult patients with chronic phase, accelerated phase or blast phase chronic myeloid leukaemia, following a recommendation from the All Wales Medicines Strategy Group.
Newer drugs are available which is aimed at delaying onset of blast phase or accelerated phase.
Phosphorylation of spleen tyrosine kinase (Syk) appears to be related to the blast phase of chronic myeloid leukemia.