(6) Although the US hantaviruses cause HPS and not HFRS like the Old World hantaviruses, both of the Southeastern hantaviruses, Bayou virus, and Black Creek Canal virus may cause HPS associated with clinical findings similar to Eurasian strain-caused HFRS, including severe myositis, renal insufficiency with elevated creatinine and blood urea nitrogen (BUN) levels, and intra-alveolar hemorrhage.
Genetic and serologic analysis of Black Creek Canal virus and its association with human disease and Sigmodon hispidus infection.
HPS case-patients by geographic region, United States, 1993-2009 * Region States ([dagger]) Southwest Arizona, California, Colorado, New Mexico, Nevada, Utah Northwest Idaho, Montana, Oregon, Washington, Wyoming Midwest Illinois, Indiana, Iowa, Kansas, Louisiana, Minnesota, North Dakota, Nebraska, Oklahoma, South Dakota, Texas, Wisconsin East Florida, Maryland, North Carolina, New York, Pennsylvania, Virginia, West Virginia Hantavirus species present in Region region Southwest Sin Nombre virus Northwest Sin Nombre virus Midwest Sin Nombre virus, Bayou virus East New York virus, Monongahela virus, Black Creek Canal virus
Hantavirus pulmonary syndrome in Florida; association with the newly identified Black Creek Canal virus
. Am J Med.
Hantaviruses maintained in rodent hosts from different genera (e.g., SNV in Peromyscus species rodents compared with Black Creek Canal virus
in Sigmodon species rodents) will clearly meet the broad criteria for separate species status.
This assay would detect (but not distinguish among) infections by New York virus (from the white-footed mouse ), Prospect Hill-like viruses (from arvicoline rodents ), El Moro Canyon virus (from the Western harvest mouse ), Black Creek Canal virus (from the cotton rat ), and Bayou virus (from the rice rat ).
Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus.
However, evidence using Black Creek Canal virus
and adult hispid cotton rats, Hantaan virus and Apodemus agrarius, and Puumala virus and Clethrionomys glareolus indicates that whereas viremia may diminish over time, virus can still be detected in various organs, including the salivary gland, for several months after infection (11 - 14).