Realizing increase in incidents of rat bites, the KP government also established a separate 'Rat bite cell
' at Lady Reading Hospital for treatment of such patients.
Blister cells are the precursors of bite cells
, which appear as red blood cells containing a peripherally located vacuole.
Peripheral blood smear showed normocytic, normochromic red blood cells that demonstrated polychromasia, anisocytosis, tear drop cells and bite cells
consistent with haemolysis.
Moreover, results of a direct Coombs test were negative, although a routine peripheral blood smear revealed the presence of "bite cells." An enzymopathy with a drug-induced acute episode of hemolytic anemia was suspected.
Direct Coombs test results were negative in the case patient; however, a peripheral blood smear revealed bite cells, which are indicative of oxidative damage to Hb (Fig.
Blood picture showed normocytic normochromic red cells with mild polychromasia, bite cells
and occasional blast cells.
Oxidative-drug-induced hemolysis ([greater than or equal to]2% bite cells
and the presence of any number of spherocytes)
This definition does not include "bite cells
" or larger schistocytic ("helmet") cells.