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any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Called also bisphosphonate.


Member of a class of drugs used for treatment of osteoporosis; works by inhibiting osteoclast-mediate resorption of bone.


Any of a class of drugs that decrease bone resorption by inhibiting osteoclasts, used in the treatment of osteoporosis, Paget's disease, bone metastases, and other conditions. Also called diphosphonate.


Any of a family of drugs with two phosphonate (PO3) groups, which inhibit enzymes that break down pyrophosphate. Bisphosphonates include etidronate and clodronate (first-generation agents), and pamidronate disodium (a second-generation bisphosphonate), which inhibits bone resorption at doses that do not affect bone mineralisation. Bisphosphonates are potent inhibitors of bone resorption that bind tightly to the hydroxyapatite crystals, and have therapeutic potential in osteoporosis and in advanced (stage-III) multiple myeloma and Paget’s disease of bone.

Treat and prevent osteoporosis, osteolysis due to metastatic breast and prostate cancer, multiple myeloma, Paget's disease of bone, fibrous dysplasia, Gaucher's disease, etc.

Adverse effect
Upset stomach, gastritis, oesophageal erosions; long-term effects include femoral fractures and an increased risk of oesophageal cancer.

Etidronate, clodronate, tiludronate.


A class of drugs used to treat Paget's disease. These drugs bind to the minerals in bone tissue and lessen the amount of bone loss associated with Paget's disease.


Member of a class of drugs used for treatment of osteoporosis; works by inhibiting osteoclast-mediate resorption of bone. bisphosphonate
References in periodicals archive ?
Studies have found that bisphosphonate use benefits the periodontium in postmenopausal women with osteoporosis.
The implication of this observational-data finding is that drug holidays from a bisphosphonate regimen "may not be appropriate for all patients," Kenneth G.
Injection (Phenergan) 10 mg intramuscularly and injection Acetaminophen 500 mg intravenous was given in case they developed shivering or body aches and pains during administration of Bisphosphonate injection; besides Bisphosphonate an oral dose of Calcium 1200 mg, Vit.
The study participants were placed in five groups, based on fracture type and bisphosphonate use.
In a multivariate analysis adjusted for age, BMI, education, race, quadriceps strength, and history of knee injury, bisphosphonate users were 41% less likely to be in the fastest bone shape-changing group and 32% less likely to be in the intermediate group, compared with the slowest-changing group.
When an insufficiency fracture is identified in a patient taking a bisphosphonate, the medication should be discontinued and a consultation with Endocrinology should be arranged.
Eight reports of atypical ulnar fractures associated with bisphosphonate use have been published [2].
In January 2016, a task force of the American Society for Bone and Mineral Research released guidelines on the optimal duration of bisphosphonate therapy in patients with osteoporosis.
Regarding this pathway, it is very important to evaluate the patients dental situation and oral hygiene before and during the bisphosphonate therapy to prevent BRONJ.
A An association has been found between bisphosphonates and "atypical" fractures in the femur (thighbone).