Birbeck granule

Lan·ger·hans gran·ule

a small, tennis racket-shaped membrane-bound granule with characteristic cross-striated internal ultrastructure; first reported in Langerhans cells of the epidermis.
See also: eosinophilic granuloma.
Synonym(s): Birbeck granule
A subcellular particle with a pentalaminar ‘handle’ and bulbous terminal dilatation of uncertain significance that is seen by electron microscopy in the antigen-presenting Langerhans’ cell and in histiocytes


Michael S., English cancer researcher.
Birbeck granule - Synonym(s): Langerhans granule

Birbeck granule

a 'tennis-racquet' organelle characteristic of human Langerhans cells; in animals occur only in Langerhans cells in cattle.
References in periodicals archive ?
The Birbeck granule, a trilaminar rod-like organelle with a terminal expansion resembling a tennis racquet, is distinctive.
The typical non-Langerhans' foamy histiocytes that lacked Birbeck granules, located in a polymorphic granuloma with xanthogranulomatosis was shown.
These cells express S100 protein, CD1a, and langerin (CD207) and contain intracytoplasmic Birbeck granules.
1,2) The major diagnostic features of LCH are expression of CD1a and S100 as well as ultrastructural Birbeck granules.
Langerhans cells are dendritic antigen presenting cells with distinctive convoluted nuclear contour, presence of Birbeck granules on electron microscopy and positive staining with S-100 and CD1a.
The presence of birbeck granules in the cytoplasm is characterictic.
Langerhans cells have cytoplasmic inclusion bodies known as Birbeck granules; a definitive diagnosis requires electron microscopy of Birbeck granules or CD 1 antigenic determinants by immunohistochemistry.
The immunoprofile is (CD1a+, S100+), and some cells should have the characteristic LC features of grooved nuclei and/or Birbeck granules.
S-100, CD 68 and CD-1a stains were positive and Birbeck granules were seen on electron microscopy (EM), confirming the diagnosis.
Some clinicians believe that the cells are precursors to Langerhans' cells, obtaining Birbeck granules as they climb into the epidermis.
Electron micrograph of follicular dendritic cell sarcoma shows well-developed, long interdigitating cytoplasmic processes and desmosome-like junctions; no Birbeck granules are seen (original magnification X20 000).
Birbeck granules are intracellular in location having a tennis racket appearance and identified by electron microscopy.