can cause effects such as hair thinning and skin rashes, particularly visible on the face of patient.
These are Phenylketonuria, endocrine insufficiency, sickle cell anaemia, congenital malformations, biotin deficiency
disease, diseases of amino acids, organic and fatty (mass spectrometer), glactosemia, Other tests include cardiac examination to detect critical congenital deformities of the heart and early screening of hearing disorders for newborns to detect hereditary deafness.
Risk for biotin deficiency
is high among pregnant women and those with Crohn's disease.
Enzyme defects indicated by solid bars are numbered as follows: (1), branched-chain 2-ketoacid dehydrogenase complex deficiency (MSUD, maple syrup urine disease); (2), isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia); (3), isolated 3-methylcrotonyl-CoA carboxylase deficiency; (4), 3-methylcrotonyl-CoA carboxylase deficiency as part of a multiple carboxylase deficiency due to nutritional biotin deficiency
or biotinidase deficiency or holocarboxylase synthetase deficiency or carbonic anhydrase VA deficiency or MT-ATP6 deficiency; (5), 3-methylglutaconyl-CoA hydratase deficiency; (6), 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase deficiency.
Psoriasis can be easily excluded clinically by the absence of silvery white scales and Auspitz sign, and histopathologically by the absence of spongiosis and necrotic keratinocytes.6 Other necrolytic erythemas such as acrodermatitis enteropathica, pellagra and biotin deficiency
can be differentiated from NAE clinically by specific predilection of sites, periorificial and mucosal involvement; more erythematous, blistering and erosive lesions while less common hyperkeratotic and verrucous lesions; and associated systemic symptoms.
may be evidenced by rashes, dry skin, seborrheic dermatitis, brittle nails, fine or brittle hair, and hair loss.
can lead to neurological disease and affect the growth of hair and skin cells.
Avidin complexes with biotin to impair its digestion , which can lead to a biotin deficiency
if consumed in large amounts that exceed the capacity of pepsin [20, 28].
Espinosa-Aguirre et al., "Biotin deficiency
and biotin excess: effects on the female reproductive system," Steroids, vol.
is almost unheard of because the vitamin is found in so many foods.
Known biotin deficiency
symptoms include body hair loss and thinning, dermatitis, dry skin, and brittle finger nails," Faustino says.
in an infant fed with amino acid formula and hypoallergenic rice.