biopterin


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bi·op·ter·in

(bī-op'ter-in),
A pterin found in yeast, the fruit fly, and in normal human urine. The reduced form of biopterin serves as a coenzyme for a number of enzyme-catalyzed reactions.

biopterin

An enzyme cofactor which is an oxidised degradation product of tetrahydrobiopterin, and involved in oxidation-reduction reactions.

biopterin

(bī-ŏp′tĕr-ĭn)
2-amino-4-hydroxy-6-(1,2-hydroxypropyl) pteridine, important in metabolizing phenylalanine. A deficiency of biopterin is a rare cause of phenylketonuria.
References in periodicals archive ?
Further evaluation of HPA occurring as a secondary consequence of a defect in the metabolism or regeneration of BH4 is done through analysis of urine or blood neopterin, biopterin and measurement of DHPR activity.
However, inflammation can also oxidate BH4 due to increasing production of ROS, which in turn forms dihydrobiopterin (BH2) and ultimately biopterin (B) [9].
BH4 concentrations, expressed as pmol/mg protein, were calculated by subtracting dihydrobiopterin (BH2) and oxidized biopterin from the total biopterins [30].
major cocktail vaccine utilized for the inoculation of mice consists of two DNA plasmids, one encoding for the antigen proteins biopterin transporter (BT) and the intercellular cell adhesion molecules (ICAM), as well as plasmids containing the open reading frame (ORFF), the transmembrane protein Amastin, and PVAX, which is the only plasmid approved by the FDA for human vaccinations due to its unstable properties that allow for its easy removal from the body and minimizes the possibility of chromosomal integration [17-20].
Nixon, "Analysis of reduced forms of biopterin in biological tissues and fluids," Analytical Biochemistry, vol.
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: Insights from cells with tet-regulated GTP cyclohydrolase I expression.
Human monocytes/macrophages lack the enzyme 6-pyruvoyltetra-hydro biopterin synthase, which converts N[H.sub.2]TP to 6pyruvoyl-tetra-hydro biopterin.
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: Relative importance of the de novo biopterin synthesis versus salvage pathways.
Evaluate the effect of atorvastatin on biopterin levels and the BH4/BH2 ratio in hypertensive type-2 diabetic patients
Mass Spectrometry of BH4, BH2, and Biopterin. The optimized electrospray ionization condition should be sensitive enough to detect BH4, DA, IS, BH2, and biopterin in positive ion detection mode.
Al-Wakeel et al., "Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status insights from cells with TET-regulated GTP cyclohydrolasei expression," Journal of Biological Chemistry, vol.