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In the lab, cryptic variation might help a biomolecule bind a new receptor.
The merged companies of PhyNexus and Biotage will be able to provide their global customers an enabling automation platform based on Dual Flow Chromatography and patented tip technology for high throughput purification of biomolecules such as proteins, plasmids and antibodies at the lab-scale.
Among their topics are reverse micellar studies, activity coefficients of amino acids in aqueous electrolyte solutions, extracting biomolecules from aqueous solutions by reverse micelles, extracting proteins from aqueous solutions by complexation using surfactants, and reactions in ionic surfactant-based emulsions and microemulsions.
The study was led by Chi Van Dang, and he explains why this occurs, saying, "Cells don't want to make proteins or other biomolecules when they're under stress.
The therapeutic utilization of complex and unique biomolecules has become commonplace in drug discovery R&D.
Dielectrophoresis (DEP), resulting from inhomogeneous electric fields, has been utilized for the specific manipulation of the particles, cells, and viruses as well as biomolecules such as DNA and even single protein, because of its simplicity, efficiency, and usability [16-18].
Since biomolecules effectively determine the courses of our lives, this work is expected to revolutionize modern medicine.
However, the researchers discovered that when illuminated with visible light, the biomolecules get excited and light up well enough to be imaged without fluorescent stains.
This allows a single resin to bind biomolecules through two or more interaction modes, which can potentially decrease the number of required purification steps in the workflow, require less sample material, offer better separation in the same time, and help in separating impurities that are very similar to the target biomolecule.
In African, herbal medicine has been a traditional approach to treating infertility for many years; however the active biomolecules and mechanism of action are still unclear.
Biomolecules is one of the fastest growing areas in drug development currently and includes monoclonal antibodies-based drugs being used for the treatment of various diseases like for example rheumatoid arthritis, and cancer.
Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can encourage stem cells in the bone marrow to differentiate into bone cells, and that specific biomolecules can inhibit or promote stem cell differentiation.