In order to explore memory from a systems biology perspective, Kulasiri and He survey recent research on modeling biochemical pathways
related to intra-cellular networks within the synapses, introduce the biology of synapses at an elementary level, and provide a succinct background to the mathematical methods related to system biology in general.
Our earlier work, funded by the Alzheimer's Research Trust, has demonstrated that many of the relevant biochemical pathways
are evolutionarily conserved between us and flies.
That concept means that we're all genetically similar in the large picture, but genetically unique in the many biochemical pathways
of our cells.
Combination drugs may in fact be more effective than single drugs, because biochemical pathways
of disease can frequently take multiple paths.
The tool described in this month's column, however, concentrates on biochemical pathways
, and these types of studies actually predate the bioinformatics "revolution" While marketed to the pharmaceutical industry as help in target selection and validation plus reduced time-to-decision, PathwayLab might be found useful by students and biochemists in those areas of research involving modeling, simulations and kinetics.
Several biochemical pathways
can produce succinate from sugar.
It is thought the narrow bandwidth light affects biochemical pathways
in the skin that improve cell viability.
A combined plant could produce ethanol or other products by biochemical pathways
, then thermochemically convert recalcitrant materials into electricity or additional fuels.
The patent also covers methods for linking the identified chemical components to metabolites in biochemical pathways
Chronic anxiety also appears to greatly increase disease progression, probably through different biochemical pathways
Growing understanding of the complex biochemical pathways
that underlie life processes has the potential to enable a class of new, more virulent biological agents engineered to attack distinct biochemical pathways
and elicit specific effects," the report says.
Enzyme cascades, such as the immune complement system or blood clotting, and biochemical pathways
are the favorite targets of the "designists" since the coordinated presence and functioning of many factors, connected in series, seems absolutely necessary for the final result to occur, i.