Moreover, it targets particular biochemical pathways
vital to the development, function, migration, and survival of certain nerve cells, says Kenneth Warren of the National Institute on Alcohol Abuse and Alcoholism in Bethesda, Md.
To address this uncertainly, scientists in the nephrotoxicity and other working groups used pathway mapping to identify biochemical pathways
that were affected upon treatment with a toxicant.
Studying fruit flies high on crack cocaine may be the next hot avenue of research for scientists bent on exposing the biochemical pathways
by which repeated ingestion of the drug leads to addiction in people.
The study led by David Litchfield of The University of Western Ontario has identified how biochemical pathways
can be "rewired" in cancer cells to allow these cells to ignore signals that should normally trigger their death.
The altered bacteria lack compounds central to three different biochemical pathways
required for their survival and growth.
"Our research sheds light on how that loss of NO might happen, and reveals biochemical pathways
that drug discoverers might be able to exploit to find new medicines for Alzheimer's," he said.
Indeed, by combining all the toxicogenomic biomarkers, scientists will construct the intricate biochemical pathways
* Researchers reported evidence that Alzheimer's disease may result from an imbalance between two biochemical pathways
for breaking down a precursor of beta amyloid, a major constituent of the brain-wrecking plaques characteristic of Alzheimer's (141: 152).
"Yeast is a very simple but powerful model in which to study how alpha-synuclein actually works as, remarkably, many of the biochemical pathways
involved are similar between yeast and humans," he said.
With their various hairy root cultues, the Penn State researchers have begun to tease apart the complex biochemical pathways
that yields these compounds.
The researchers targeted one of the many biochemical pathways
inside the mosquito's cells.
The ability to disrupt vertebrate reproduction is clearly present in plants, the relevant biochemical pathways
are available to plants, and the risks to plant reproduction are minimal.