Many phytochemicals stimulate the biochemical pathways
that detoxify and excrete drugs, rather than turn them into carcinogens.
mVision's unbiased and non-targeted approach to biomarker discovery allows scientists to observe drug- or disease- induced biochemical changes over virtually the entire spectrum of biochemical pathways
The memory-boosting chemical was singled out from among 100,000 chemicals screened at the Small Molecule Discovery Center at UCSF for their potential to perturb a protective biochemical pathway
within cells that is activated when cells are unable to keep up with the need to fold proteins into their working forms.
In this challenge, Thornton has hormone evolution begin at the end of the biochemical pathway
Once localized at the neovasculature, the siRNA blocks a key biochemical pathway
in blood vessel formation that reduces nutrient supply to the tumor.
This research, published in the April 30th issue of the scientific journal Cell, provides compelling evidence for the existence of a new biochemical pathway
that may lead to the discovery of new drugs for the treatment of proliferative disorders.
Here, researchers identified a novel biochemical pathway
in which the circadian regulatory gene CRY was found to up-regulate expression of a gene which promotes the activation of TNF-alpha (tumour necrosis factor-alpha, a pro-inflammatory cytokine used by the body to boost the immune system) by two fold, when comparing mice with the CRY gene removed to those with a normal copy of the gene.
The scientists fused a gene from a luminescent marine bacterium into the soil bacterium's gene sequence associated with a biochemical pathway
for breaking down naphthalene.
Undoubtedly there are other important genes to be found in the general biochemical pathway
by which plants resist disease (SN: 8/14/93, p.
Cambridge Healthtech Institute's (CHI's) new report, Biochemical Pathway
and Systems Analysis for Target Identification and Validation, analyzes this burgeoning area of drug discovery and development.
For instance, "an enzyme in a biochemical pathway
'reads' the concentration of its substrate and produces a corresponding level of product.
Mello studies both the biochemical pathway
responsible for RNAi and the regulation of gene expression.