artificial liver

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An extracorporeal supportive device for a person with acute liver failure. Bioartificial livers are not intended as permanent replacements, but as stop-gaps while one is awaiting liver transplantation. The current generation devices contain hepatocytes embedded in a gel. The patient’s plasma is removed and circulated through the device and returned, minus the metabolic wastes produced by the body which are normally removed by a healthy liver
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

artificial liver

Biotech A cartridge with cloned human liver cells, through which blood flows to facilitate removal of waste products. See Extracorporeal liver assist device, Liver dialysis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

artificial liver

A biomechanical device typically combining a system of filters to remove toxins from the blood with hepatic cells or tissue. It is designed to support patients with hepatic failure temporarily until a donor liver becomes available for transplantation.
See also: liver
Medical Dictionary, © 2009 Farlex and Partners

artificial liver

An as yet unrealized entity that is, nevertheless, the subject of promising research and development. Current ambitions are to produce extracorporeal devices that will enable patients with liver failure to be kept alive until regeneration of transplantation is achieved. The principal difficulty arises from the large number of different metabolic functions performed by the liver. A promising approach is the use of cloned human liver cells grown around numerous fine semipermeable tubules through which the patient's blood is passed.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Bioartificial Liver Innovation Shows Potential to Avoid Transplants
Lee et al., "Functional Evaluation of a Bioartificial Liver Support System Using Immobilized Hepatocyte Spheroids in a Porcine Model of Acute Liver Failure," Scientific Reports, vol.
Papoutsidakis et al., "Bioartificial liver attenuates intestinal mucosa injury and gut barrier dysfunction after major hepatectomy: study in a porcine model," Surgery, vol.
Nyberg, "Artificial and bioartificial liver support," Seminars in Liver Disease, vol.
Yan et al., "Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes," Cell Research, vol.
Glycine also acts as the protective agent on gel entrapped hepatocytes in bioartificial liver. 3 mM of glycine has maximum protective ability and glycine can suppress cell necrosis after exposure to anoxia [60].
Upcyte hepatocytes are functionally equivalent to human primary liver cells and therefore suitable for use in cell-based bioartificial liver systems.
Summary: Bioartificial Liver Trial Now at Halfway Point .
However, further studies need to be performed for the development of a bioartificial liver system.
Isolation and culture of pig hepatocyte in large scale for the application of bioartificial liver system.