artificial liver

(redirected from Bioartificial Liver)
An extracorporeal supportive device for a person with acute liver failure. Bioartificial livers are not intended as permanent replacements, but as stop-gaps while one is awaiting liver transplantation. The current generation devices contain hepatocytes embedded in a gel. The patient’s plasma is removed and circulated through the device and returned, minus the metabolic wastes produced by the body which are normally removed by a healthy liver

artificial liver

Biotech A cartridge with cloned human liver cells, through which blood flows to facilitate removal of waste products. See Extracorporeal liver assist device, Liver dialysis.

artificial liver

A biomechanical device typically combining a system of filters to remove toxins from the blood with hepatic cells or tissue. It is designed to support patients with hepatic failure temporarily until a donor liver becomes available for transplantation.
See also: liver

artificial liver

An as yet unrealized entity that is, nevertheless, the subject of promising research and development. Current ambitions are to produce extracorporeal devices that will enable patients with liver failure to be kept alive until regeneration of transplantation is achieved. The principal difficulty arises from the large number of different metabolic functions performed by the liver. A promising approach is the use of cloned human liver cells grown around numerous fine semipermeable tubules through which the patient's blood is passed.
References in periodicals archive ?
Upcyte hepatocytes are functionally equivalent to human primary liver cells and therefore suitable for use in cell-based bioartificial liver systems.
Life support of artificial liver: development of a bioartificial liver to treat liver failure.
Summary: Bioartificial Liver Trial Now at Halfway Point .
However, further studies need to be performed for the development of a bioartificial liver system.
Isolation and culture of pig hepatocyte in large scale for the application of bioartificial liver system.
Today's results demonstrate that, while inside our bioartificial liver device, HepaLife's PICM-19 cells are able to produce substantial amounts of urea and remove toxic ammonia, while remaining healthy, and replicating important liver-like functions," stated Frank Menzler, president and CEO of HepaLife.
The Arbios product candidate portfolio includes the SEPET Liver Assist Device, a novel blood purification therapy that provides enhanced "liver dialysis," and the HepatAssist Cell-Based Liver Support System, a bioartificial liver that combines blood detoxification with liver cell therapy to replace whole liver function in patients with the most severe forms of liver failure.
The trial is studying a bioartificial liver treatment in patients with chronic liver disease at Beijing Youan and 302 Military Hospitals in Beijing.
Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support.
An extracorporeal bioartificial liver that uses pig hepatocytes appears to significantly improve survival of patients either with acute liver failure or after unsuccessful liver transplantation, according to the first randomized, multicenter trial of its kind.
Algenix, a biomedical liver disease management company, has developed a bioartificial liver, the [Liver.