binding site

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binding site

(1) Antigen-binding site, see there.
(2) A nonspecific term for any site at which two or more molecules join as a part of a reaction.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

binding site

an area of an ENZYME to which other molecules can attach. Such an area can be an ACTIVE SITE for particular substrates or for other molecules, as in COMPETITIVE INHIBITION. Alternatively, some enzymes possess two binding sites, one for substrate attachment, the other for attachment of other molecules as in noncompetitive inhibition and allosteric inhibition (see ALLOSTERIC INHIBITORS).
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Patient discussion about binding site

Q. My friend has Progressive MS, he is bound to a wheelchair, Prognosis? How can I help? He must be moved by a Hoyer Lift, he has caregivers. He has a beautiful voice and does have enough ability to move in his chair around local community. He has some bad days with spacicity, I want to help but am unsure as to how? He is 60? or so and lives on his own, he has had MS for many years and a number of complications, such as pneumonia and decubitus. Please help me to help him!

A. There are a number of ideas and resources for social and recreational activities (i.e. wheelchair sports, dancing, travel, aviation, etc.) that may be helpful, which can be found at

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References in periodicals archive ?
It comprises three distinct drug binding domains which include taxol, vincaalkaloid and colchicine binding sites. Drugs associated with these sites were religiously involved in arresting the mitotic spindle formation (25).
We mapped the ligand binding sites and their ET status onto the chain A of crystal structures of BACE1 (1FKN) and BACE2 (2EWY) (Figure 5).
"Now that we've identified this key brain protein and understand its structure, it's possible to imagine developing a drug that could block the binding site," Adron Harris, professor of biology and director of the Waggoner Center for Alcohol and Addiction at The University of Texas at Austin, said.
The choline ends can occupy multiple choline binding sites of the CBP simultaneously.
Like the THF-diols, this novel endocrine-disruptive agent derived from fatty acid metabolism in plants does not bind to ER or nuclear type II [[sup.3]H]estradiol binding sites and thus antagonizes estrogenic response through nonclassical pathways (Maggiolini et al.
"The technique, referred to as 'NMR Solve,' allows us to quickly and cost-effectively determine structural information specific to a protein's binding sites without the need to determine the structure of the entire protein," said Dan Sem, Ph.D., Vice President, Triad Therapeutics, and inventor on the patent .
Seven different nanoparticle-antibody Mab 5A10 bioconjugates with 8-130 binding sites for PSA on a single nanoparticle had been characterized in detail previously (17).
The study published in the Proceedings of the National Academy of Sciences (PNAS) gives the first clear details of how the binding sites of CaMKII act to align actin filaments into long, rigid bundles.
With new genome mapping technology, these findings provide a crucial understanding of mutations that result at ETS binding sites located in specific genes that are known to be drivers in the onset of melanoma in humans.
Instead, they contain shorter sub-sequences, which are recognized as binding sites for a class of proteins known as transcription factors (TFs); there are a great many of these, each with their own preferred DNA sequence binding site (usually short, 10-20 base pairs) and their own level of ability to recruit in RNA polymerase.