association constant

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Related to Binding constant: association constant

as·so·ci·a·tion con·stant

1. in experimental immunology, a mathematical expression of hapten-antibody interaction: average association constant, K = [hapten-bound antibody]/[free antibody][free hapten];
2. the equilibrium constant involved in the association of two or more compounds or ions into a new compound; the reciprocal of the dissociation constant.
Synonym(s): binding constant
References in periodicals archive ?
Plotting lg[(A0-A)/A] according to lg[Dt] gives the binding constant K and the binding sites n according to the slope.
The binding constant for fluoride was calculated from the relative changes in the integrated intensity of NH signals for the free receptor and the complex, yielding a binding constant larger than [10.sup.4] [M.sup.-1] (Portis et al, 2017).
HBCD-RNA binding constant was determined as demonstrated previously in UV-Visible spectroscopy (Figure 5A).
CT-DNA study yields intrinsic binding constants by the arrangement attributing to Hammett's postulation.
Fluorescence anisotropy is widely used to measure the binding constants and kinetics of reactions that cause a change in the rotational time of the fluorescent molecules [24].
From the plots the binding constants (K) for the 1: 1 luteolin/CB7 and EGCG/CB7 complexes were calculated to be 3.2 x [10.sup.3] and 4.8 x [10.sup.3] [M.sup.-1], respectively.
Such surface contact was substantiated by quantitative calculations from (1) for their intrinsic binding constant ([K.sub.b]) and the obtained values are 6.01 x [10.sup.4], 8.16 x [10.sup.5], 5.95 x [10.sup.4], and 7.86 x [10.sup.4] for complexes [C.sub.1], [C.sub.2], [C.sub.3], and [C.sub.4], respectively, which is comparable to a potential intercalator (for EB whose Kb have been found to be in the order of 106-107 M-1) [55, 56].
Furthermore, UV-vis and fluorescence measurements could obtain information related to the binding mechanisms between small molecules and DNA, such as molar ratio, binding modes, binding constants, quenching rate constants, and thermodynamic parameters [29].
where [F.sub.0] and F are the fluorescence intensities at 338 nm before and after the addition of the quencher and [L] and [[P.sub.t]] are the ligand and the total protein concentrations, respectively The number of binding sites (n) and the binding constant ([K.sub.b]) were obtained by plotting log(([F.sub.0] - F)/F) versus log(1/([[L.sub.t]] - n([F.sub.0] - F)[[P.sub.t]]/[F.sub.0])) using the reiterative calculation process described by Sun et al.
2b) and the value of the binding constant (K) for HSA-cisplatin derivative complex is found to be 0.2392 x [10.sup.4] [M.sup.-1].
8,921,299 B2; The Procter & Gamble Company has patented a detergent composition comprising tiron (1,2-dihydroxybenzene-3,5-disulfonic acid, or mono- or di-sulfonate salts of the acid); a ligand capable of chelating to Fe3+, wherein the ligand has a binding constant for Fe3+ that is greater than 1018 M-1, and wherein the ligand is selected from the group consisting of aminocarboxylates containing at least two N atoms, amino-phosphonates containing at least two N atoms, and geminal bisphosphonates; an iron-displacing species selected from the group consisting of phenyl boronic acid, A13+' and mixtures thereof; and at least about 0.2 ppm Fe3+.