cholangiocarcinoma

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cholangiocarcinoma

 [ko-lan″je-o-kahr″sĭ-no´mah]
1. an adenocarcinoma arising from the epithelium of the intrahepatic bile ducts, composed of eosinophilic cuboidal or columnar epithelial cells, with abundant fibrous stroma; mucus may be secreted but not bile.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kar'si-nō'mă),
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma; cirrhosis is usually absent.

cholangiocarcinoma

A rare (5/105/year) cancer of intrahepatic bile ducts, seen > age 60.
 
Aetiology
Anabolic steroids, liver flukes (Clonorchis sinensis), ulcerative colitis, cholecystitis, cholelithiasis, primary sclerosing cholangitis, malformations, cirrhosis.

Clinical findings
Obstruction, jaundice, abdominal pain, weight loss.

Location
Hilar, 50–60%; intrahepatic, 10%; extrahepatic 20–30%.

Prognosis
53% 1-year survival; 4% 5-year survival.

cholangiocarcinoma

Bile duct cancer, cancer of bile ducts A rare–5/100,000/yr cancer of intrahepatic bile ducts seen > age 60 Etiology Anabolic steroids, Thorotrast,.Clonorchis sinensis, possibly ulcerative cholitis, cholecystitis; not associated with alcohol abuse Clinical Jaundice—71%, abdominal pain-49%, weight loss—44% Prognosis 53% 1-yr survival, 9% 3-yr, 4% 5-yr. Cf Hepatocellular carcinoma.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kahr-si-nō'mă)
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma.

cholangiocarcinoma

Cancer of the bile ducts.
References in periodicals archive ?
Pancreatic adenocarcinomas (64.5%) and bile duct carcinomas (30.4%) constituted the vast majority of tumors detected on BDBs in our cohort and had a 2:1 ratio.
Even when bile duct carcinomas are diagnosed antemortem, there is little available information on appropriate or effective treatment of this type of neoplasm in avian species.
(39) Therefore, when a tumor is centered in the bile duct, we are inclined to favor the diagnosis of bile duct carcinoma. Otherwise, we are hesitant to make a diagnosis of distal bile duct carcinoma, regardless of the extent of bile duct involvement.
The IHCC cases tend to differ morphologically from perihilar and distal bile duct carcinomas, which instead resemble PDACs.
Ampullary and distal bile duct carcinomas. A, Gross photo of an ampullary carcinoma (arrow).
Both primary sclerosing cholangitis and bile duct carcinomas can be associated with a dense, chronic, inflammatory infiltrate and more [IgG4.sup.+] plasma cells.
The number of metastatic lymph nodes in extrahepatic bile duct carcinoma as a prognostic factor [published correction appears in Am J Surg Pathol.
Measurement of the invasion depth of extrahepatic bile duct carcinoma: an alternative method overcoming the current T classification problems of the AJCC staging system.
E: Margins.--Locoregional recurrence, as opposed to distant metastases, is usually the first site of disease recurrence and occurs in up to 59% of patients with perihilar bile duct carcinomas. (6) Tumor recurrence is often related to residual tumor located in the proximal or distal surgical margins of the bile duct or from tumor located along the dissected soft tissue margin in the portal area.
Complete surgical resection with microscopically negative surgical margins is an important predictor of outcome in multivariate analysis for both perihilar and distal bile duct carcinomas, with overall 5-year survival for perihilar tumor improved from 10% for all patients to 30% for those with negative resection margins.
The regional nodes for distal bile duct carcinomas are the same as those for carcinomas of the pancreatic head and include the following: lymph nodes along the common bile duct, hepatic artery, and celiac trunk; posterior and anterior pancreaticoduodenal nodes; and nodes along the superior mesenteric vein and the right lateral wall of the superior mesenteric artery.
Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis.