bile acid sequestrant


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bile acid sequestrant

Any of a family of cholesterol-lowering agents—e.g., cholestipol, cholestyramine—that bind with cholesterol-containing bile acids in the intestine and remove them in stool.

Adverse effects
Constipation, diarrhoea, flatulence.

bile acid sequestrant

Any of a class of polymeric resins that binds bile acids and prevents these cholesterol-containing compounds from recirculating into the blood from the gastrointestinal tract. Medications from this class are used to treat those with high serum cholesterol levels and to reduce itching in patients with chronic liver diseases.
See also: sequestrant

bile acid sequestrant

A drug that binds to bile acids that have entered the intestine via the bile duct, so altering them that they cannot be absorbed back into the bloodstream in the usual way and are excreted in the faeces. Cholesterol is converted to bile acids by the liver. Loss of bile acids means more conversion of cholesterol and a lowering in total body cholesterol.
References in periodicals archive ?
This fatal case of ischemic colitis showed abundant Kayexalate (arrow) and bile acid sequestrant (BAS) resins (bracket, asterisks) at the perforation site.
Colesevelam hydrochloride (cholestagel): a new, potent bile acid sequestrant associated with a low incidence ofgastrointestinal side effects.
Adding a bile acid sequestrant to statin monotherapy does not appear to increase the risk of systemic toxicity.
Recommended pharmacologic interventions include HMG-CoA reductase inhibitors (statins), bile acid sequestrants, nicotinic acid, and fibric acids (Reed et al.
Therefore, health care providers should be aware that other lipid-lowering medications, such as bile acid sequestrants, fibric acids, and niacin have the advantageous effect of raising HDL-C level (Illingworth, 2001).
moderately high risk) Intensity lifestyle changes, consider (1) statin, (2) bile acid sequestrant.
A bile acid sequestrant should not be used by patients with high triglycerides; it will worsen the problem.
The statins, Vytorin and Zetia predominantly target LDL-C so patients with elevated triglycerides or decreased HDL even after treatment with one of these agents are often prescribed an add-on drug such as niacin, a fibrate, omega-3 fatty acid or bile acid sequestrant to target these lipid abnormalities," said Decision Resources Analyst Christine Helliwell, Ph.
The internist will lose the case because he should have chosen a statin over a bile acid sequestrant.
Because co-administration of bile acid sequestrants may reduce the bioavailability of acidic medicinal products such as nicotinic acid, it is recommended that Tredaptive be administered > 1 hour before or > 4 hours after administration of a bile acid sequestrant (see section 4.
University, examined the interaction of levothyroxine with two relatively new drugs--colesevelam (Welchol), the newest bile acid sequestrant approved for hyperlipidemia and diabetes; and lanthanum carbonate (Fosrenol), a new phosphate binder used in end-stage renal disease.
Colesevelam hydrochloride (HCI) is a bile acid sequestrant indicated alone or in combination with a statin, and as an adjunct to diet and exercise, for the reduction of elevated low-density lipoprotei n-cholesterol (LDL-C) in patients with primary hypercholesterolemia.