bile acid sequestrant


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bile acid sequestrant

Any of a family of cholesterol-lowering agents—e.g., cholestipol, cholestyramine—that bind with cholesterol-containing bile acids in the intestine and remove them in stool.

Adverse effects
Constipation, diarrhoea, flatulence.

bile acid sequestrant

Any of a class of polymeric resins that binds bile acids and prevents these cholesterol-containing compounds from recirculating into the blood from the gastrointestinal tract. Medications from this class are used to treat those with high serum cholesterol levels and to reduce itching in patients with chronic liver diseases.
See also: sequestrant

bile acid sequestrant

A drug that binds to bile acids that have entered the intestine via the bile duct, so altering them that they cannot be absorbed back into the bloodstream in the usual way and are excreted in the faeces. Cholesterol is converted to bile acids by the liver. Loss of bile acids means more conversion of cholesterol and a lowering in total body cholesterol.
References in periodicals archive ?
The bile acid sequestrants (BAS) target bile acids and are mainly used to treat diarrhea.
Bile acid sequestrants (cholestyramine [Questran[R]], colestipol [Colestid[R]], colesevelam [WelChol[R]]) inhibit the intestinal reabsorption of bile, thus increasing the amount excreted in the stool (Durstine et al., 2003).
Unfortunately, the older bile acid sequestrants have multiple drug interactions (ie, warfarin, digitalis, phenobarbital), and patients dislike them, since they must remember to take other medications >1 hour before or >4 hours later (these problems are not seen with colesevelam, a newer drug).
Agents such as bile acid sequestrants, niacin, and fibric acid compounds are commonly added to the statin drug regimen to further cholesterol reduction.
Drug Dosage Cost/Day * atorvastatin 5-80 mg/day $1.16 (5 mg) (Lipitor) fluvastatin 20-80 mg/day $1.48 (Lescol) (40 mg) lovastatin 20-80 mg/day $2.39 (20 mg) pravastatin 10-40 mg/day $2.78 (20 mg) (Pravachol) simvastatin 5-80 mg/day $2.53 (Zocor) (10 mg) NIACIN niacin, extended- 1-2.5 g/day $1.41 (1 g) release (Niaspan) BILE ACID SEQUESTRANTS cholestyramine 4-16 g/day $2.96 (8 g) colesevelam 2.5-3.75 $4.74 (WelChol) g/day (3.75 g) colestipol 5-20 g/day $2.40 (5 g) (Colestid) FIBRATES gemfibrozil 600 mg b.i.d $1.98 fenofibrate 200 mg/day $2.58 (Tricor) Drug Comment ** atorvastatin Most widely prescribed statin, most (Lipitor) potent LDL reducer, and the sole statin not backed by a larger clinical trial demonstrating reductions in acute Ml, mortality, and other key end points.
Three subsequent clinical trials reported in 2008 evaluated the glucose and lipid-lowering effects of colesevelam HC1, which is a specifically engineered bile acid sequestrant developed in the 1990s as a high-affinity, high-capacity bile acid-binding molecule.
Weitzman, an endocrinologist at Stony Brook University, New York, examined the interaction of levothyroxine with two relatively new drugs--colesevelam (Welchol), the newest bile acid sequestrant approved for hyperlipidemia and diabetes; and lanthanum carbonate (Fosrenol), a new phosphate binder used in end-stage renal disease.
The bile acid sequestrant colesevelam HCl, sold under the name WelChol, has been approved in the United States for LDL cholesterol lowering since 2000.
Budesonide is a locally acting corticosteroid that Puma believes targets the inflammation identified in a preclinical model of neratinib-induced diarrhea and colestipol is a bile acid sequestrant that Puma believes targets potential bile acid malabsorption that could result from such inflammation.
One new drug that is expected to be approved in the coming year is a variant of a bile acid sequestrant that can be taken as a capsule or a tablet.
In the past, niacin, fenofibrates, bile acid sequestrants and fish oil were widely used to help normalize blood lipid levels.
The weight loss drugs Orlistat or Olestra, and the cholesterol-lowering bile acid sequestrants Choletryamine, Colestipol, and Colsevelam can block fat absorption, creating a potential for vitamin K deficiency since it is fat-soluble.