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Oophorectomy is the surgical removal of one or both ovaries. It is also called ovariectomy or ovarian ablation. If one ovary is removed, a woman may continue to menstruate and have children. If both ovaries are removed, menstruation stops and a woman loses the ability to have children.


Oophorectomy is performed to:
  • remove cancerous ovaries
  • remove the source of estrogen that stimulates some cancers
  • remove large ovarian cysts in women with polycystic ovarian syndrome (PCOS)
  • excise an abscess
  • treat endometriosis
  • lower the risk of an ectopic pregnancy
  • lower the risk of cancer in a woman with a family history of ovarian or breast cancer
In an oophorectomy, one or a portion of one ovary may be removed or both ovaries may be removed. When oophorectomy is done to treat ovarian cancer or other spreading cancers, both ovaries are always removed. This is called a bilateral oophorectomy. Oophorectomies are sometimes performed on pre-menopausal women who have estrogen-sensitive breast cancer in an effort to remove the main source of estrogen from their bodies. This procedure has become less common than it was in the 1990s. Today, chemotherapy drugs are available that alter the production of estrogen and tamoxifen blocks any of the effects any remaining estrogen may have on cancer cells.
In younger women with low-grade or early-stage ovarian tumors who have not yet completed their families, the surgeon may perform a unilateral oophorectomy. This approach is called fertility-saving or fertility-sparing surgery. Women who are appropriate candidates for this type of oophorectomy do not have higher rates of cancer recurrence than women who have both ovaries removed.
Until the 1980s, women over age 40 having hysterectomies (surgical removal of the uterus) routinely had healthy ovaries and fallopian tubes removed at the same time. This operation is called a bilateral salpingo-oophorectomy. Many physicians reasoned that a woman over 40 was approaching menopause and soon her ovaries would stop secreting estrogen and releasing eggs. Removing the ovaries would eliminate the risk of ovarian cancer and only accelerate menopause by a few years.
In the 1990s, the thinking about routine oophorectomy began to change. The risk of ovarian cancer in women who have no family history of the disease is less than 1%. Meanwhile, removing the ovaries increases the risk of cardiovascular disease and accelerates osteoporosis unless a woman takes prescribed hormone replacements. In addition, other studies indicate that a bilateral oophorectomy increases a woman's risk of developing thyroid cancer. Women with mild endometriosis can often be successfully treated with birth control pills or other hormone medications without having to undergo surgery.
Under certain circumstances, oophorectomy may still be the treatment of choice to prevent breast and ovarian cancer in certain high-risk women. A study done at the University of Pennsylvania and released in 2000 showed that healthy women who carried the BRCA1 or BRCA2 genetic mutations that predisposed them to breast cancer had their risk of breast cancer drop from 80% to 19% when their ovaries were removed before age 40. Women between the ages of 40 and 50 showed less risk reduction, and there was no significant reduction of breast cancer risk in women over age 50.
Overall, ovarian cancer still ranks low on a woman's list of health concerns: It accounts for only 4% of all cancers in women. But the lifetime risk for developing ovarian cancer in women who have mutations in BRCA1 is significantly increased over the general population and may cause an ovarian cancer risk of 30% by age 60. For women at increased risk, oophorectomy may be considered after the age of 35 if childbearing is complete.
The value of ovary removal in preventing both breast and ovarian cancer has been documented. However, there are disagreements within the medical community about when and at what age this treatment should be offered. Preventative oophorectomy, called preventative bilateral oophorectomy (PBO), is not always covered by insurance. One study conducted in 2000 at the University of California at San Francisco found that only 20% of insurers paid for PBO. Another 25% had a policy against paying for the operation, and the remaining 55% said that they would decide about payment on an individual basis.


There are situations in which oophorectomy is a medically wise choice for women who have a family history of breast or ovarian cancer. However, women with healthy ovaries who are undergoing hysterectomy for reasons other than cancer should discuss with their doctors the benefits and disadvantages of having their ovaries removed at the time of the hysterectomy. It is important for women to ask questions about the long-term risks of a bilateral oophorectomy; one study published in 2003 reported that many women awaiting surgery felt that they did not have adequate information about their treatment options and were unaware of the possible long-term consequences to health.


Oophorectomy is done under general anesthesia. It is performed through the same type of incision, either vertical or horizontal, as an abdominal hysterectomy. Horizontal incisions leave a less noticeable scar, but vertical incisions give the surgeon a better view of the abdominal cavity.
After the incision is made, the abdominal muscles are pulled apart, not cut, so that the surgeon can see the ovaries. Then the ovaries, and often the fallopian tubes, are removed.
Oophorectomy can sometimes be done with a laparoscopic procedure. With this surgery, a tube containing a tiny lens and light source is inserted through a small incision in the navel. A camera can be attached that allows the surgeon to see the abdominal cavity on a video monitor. When the ovaries are detached, they are removed though a small incision at the top of the vagina. The ovaries can also be cut into smaller sections and removed.
The advantages of abdominal incision are that the ovaries can be removed even if a woman has many adhesions from previous surgery. The surgeon gets a good view of the abdominal cavity and can check the surrounding tissue for disease. A vertical abdominal incision is mandatory if cancer is suspected. The disadvantages are that bleeding is more likely to be a complication of this type of operation. The operation is more painful than a laparoscopic operation and the recovery period is longer. A woman can expect to be in the hospital two to five days and will need three to six weeks to return to normal activities.


Before surgery, the doctor will order blood and urine tests, and any additional tests such as ultrasound or x rays to help the surgeon visualize the woman's condition. The woman may also meet with the anesthesiologist to evaluate any special conditions that might affect the administration of anesthesia. A colon preparation may be done, if extensive surgery is anticipated.
On the evening before the operation, the woman should eat a light dinner, then take nothing by mouth, including water or other liquids, after midnight.


After surgery a woman will feel some discomfort. The degree of discomfort varies and is generally greatest with abdominal incisions, because the abdominal muscles must be stretched out of the way so that the surgeon can reach the ovaries.
When both ovaries are removed, women who do not have cancer are started on hormone replacement therapy to ease the symptoms of menopause that occur because estrogen produced by the ovaries is no longer present. If even part of one ovary remains, it will produce enough estrogen that a woman will continue to menstruate, unless her uterus was removed in a hysterectomy. Antibiotics are given to reduce the risk of post-surgery infection.
Return to normal activities takes anywhere from two to six weeks, depending on the type of surgery. When women have cancer, chemotherapy or radiation are often given in addition to surgery. Some women have emotional trauma following an oophorectomy, and can benefit from counseling and support groups.


Oophorectomy is a relatively safe operation, although, like all major surgery, it does carry some risks. These include unanticipated reaction to anesthesia, internal bleeding, blood clots, accidental damage to other organs, and post-surgery infection.
Complications after an oophorectomy include changes in sex drive, hot flashes, and other symptoms of menopause if both ovaries are removed. Women who have both ovaries removed and who do not take estrogen replacement therapy run an increased risk for cardiovascular disease and osteoporosis. Women with a history of psychological and emotional problems before an oophorectomy are more likely to experience psychological difficulties after the operation.

Normal results

If the surgery is successful, the ovaries will be removed without complication, and the underlying problem resolved. In the case of cancer, all the cancer will be removed.

Abnormal results

Complications may arise if the surgeon finds that cancer has spread to other places in the abdomen. If the cancer cannot be removed by surgery, it must be treated with chemotherapy and radiation.
Ovarian remnant syndrome is a complication that results in about 18% of women who have had an oophorectomy for severe endometriosis. The syndrome is characterized by chronic pelvic pain and/or a pelvic mass; it is treated by further surgery to remove the remaining ovarian tissue.



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Key terms

Cyst — An abnormal sac containing fluid or semisolid material.
Ectopic pregnancy — A pregnancy that develops when a fertilized egg implants outside the uterus, usually in the Fallopian tubes, but sometimes in the ovary itself.
Endometriosis — A benign condition that occurs when cells from the lining of the uterus begin growing outside the uterus.
Fallopian tubes — Slender tubes that carry ova from the ovaries to the uterus.
Hysterectomy — Surgical removal of the uterus.
Osteoporosis — The excessive loss of calcium from the bones, causing the bones to become fragile and break easily.
Polycystic ovarian syndrome (PCOS) — A condition in which the eggs are not released from the ovaries and instead form multiple cysts.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.


removal of one or both ovaries; done for tumors, severe infection, or certain other ovarian disorders. If this is done to a girl who has not yet reached puberty, it prevents the development of secondary sex characters. If both ovaries are removed from an adult woman, reproduction is not possible and the female sex hormones estrogen and progesterone are no longer produced. Called also ovariectomy.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Excision of one or both ovaries.
Synonym(s): oophorectomy
[ovario- + G. ektomē, excision]
Farlex Partner Medical Dictionary © Farlex 2012


n. pl. oophorecto·mies
Surgical removal of one or both ovaries. Also called ovariectomy.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Ovariectomy Gynecology Surgical excision of one or both ovaries. See Prophylactic oophorectomy.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


Excision of one or both ovaries.
Synonym(s): oophorectomy.
[ovario- + G. ektomē, excision]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


Surgical removal of one or both ovaries. Removal of one OVARY has little effect, but loss of both causes sterility and has secondary effects from a reduction in sex hormone production, especially OESTROGEN.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The patients included into the study were those sexually active and healthy patients, aged between 40-60, who underwent treatment between May 2013 and December 2013 in the Istanbul Gulhane Military Medical Academy, Haydarpasa Training Hospital, Obstetrics and Gynaecology Service, Suleymaniye Training and Research Hospital and Namik Kemal University Medical Faculty Hospital, These were patients with no diagnosis of malignancy, planning to have an operation of Type 1 hysterectomy and bilateral salpingo-oophorectomy and subsequently having this kind of operation.
Spinillo, "Robotic single site hysterectomy with bilateral salpingo-oophorectomy in female to male transsexualism," The Journal of Sexual Medicine, vol.
Total abdominal hysterectomy, bilateral salpingo-oophorectomy, and peritoneal washings were performed.
Mortality after bilateral salpingo-oophorectomy in ESRCA1 and BRCA2 mutation carriers.
For women diagnosed with HNPCC, researchers at the University of California, San Francisco, reported that prophylactic hysterectomy with bilateral salpingo-oophorectomy would be more cost effective than annual screenings or medical examinations for gynecologic cancers.
Surgery may also be an unilateral salpingo-oophorectomy (surgery to remove one of the ovaries and the fallopian tube, the tube that connects the ovary to the uterus) or a combination of a hysterectomy (surgery to remove the uterus), a bilateral salpingo-oophorectomy (surgery remove both of the ovaries and fallopian tubes), and an omentectomy (partial removal of the fatty lining of the abdominal cavity, where the cancer tends to spread).
BSO = bilateral salpingo-oophorectomy; DHEA = dehydroepiandrosterone: FAI = flee androgen index; FSD = female sexual dysfunction; SHBG = sex hormone-binding globulin: TAH = total abdominal hysterectomy
The patient then underwent anterior exenteration (radical cystectomy, hysterectomy, and bilateral salpingo-oophorectomy) and ileal loop urinary diversion.
Surgical ovarian ablation with bilateral salpingo-oophorectomy is a valuable strategy in the adjuvant therapy of premenopausal breast cancer, particularly among BRCA mutation carriers and women with hormone receptor-positive disease, or among women who find adherence to medical ablation difficult.
In the past 50 years, all patients were initially treated by TAH with bilateral salpingo-oophorectomy (BSO).
The seizure caused hypovolemic shock, tachycardia, and massive hemorrhaging and required an emergency hysterectomy and bilateral salpingo-oophorectomy. The patient has no children and has been rendered unable to conceive.
In fact, it is reasonable to perform the operation after the genotype result reported, if that was the case, bilateral salpingo-oophorectomy should be performed at the same operation and the second operation could be saved.

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