castration

(redirected from Bilateral Orchiectomy)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to Bilateral Orchiectomy: orchidectomy

castration

 [kas-tra´shun]
excision of the gonads (bilateral orchiectomy in a male or bilateral oophorectomy in a female), or destruction of the gonads, as by radiation or parasites. If this occurs before puberty, secondary sex characters will fail to develop. See also eunuch.
female castration removal of the ovaries, or bilateral oophorectomy; called spaying in female animals.
male castration bilateral orchiectomy.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cas·tra·tion

(kas-trā'shŭn),
1. Removal of the testicles or ovaries.
2.
Farlex Partner Medical Dictionary © Farlex 2012

castration

The removal of gonads; castration occurs in various contexts:
1. Forensic–a controversial procedure intended to ↓ sexual drives in repeat sex offenders.
2. Pathologic–due to infection, which renders both testes functionally inactive–eg, with filariasis in elephantiasis.
3. Therapeutic–to remove the source of androgens in Pts with androgen-sensitive prostate CA–which can also be accomplished by RT. See Chemical castration, Medical castration, Surgical castration Psychiatry The fantasized loss of the genitals; a mental state of impotence, powerlessness, helplessness, or defeat Urology Surgical removal of testes in ♂ with androgen-dependent prostate CA.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

cas·tra·tion

(kas-trā'shŭn)
1. Removal of the testicles or ovaries.
2. See: castration complex; castrate
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

castration

The removal of the testicles (orchidectomy or orchiectomy), or, sometimes, of all the male external genitalia. The term is also occasionally used to refer to the removal of the ovaries in women. Castration can be valuable in the treatment of androgen dependent cancer of the prostate gland, even if widespread.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

castration

see EMASCULATION (2).

castration

or

gelding

) the removal of the testicles.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Huggins,

Charles B., Canadian-U.S. surgeon and Nobel laureate, 1901-1994.
Huggins operation - orchidectomy performed for palliation or cure of cancer of the prostate. Synonym(s): castration
Medical Eponyms © Farlex 2012
References in periodicals archive ?
According to the literature, this is the second reported case with bilateral orchiectomy and amputation of the penis due to Fournier\'s gangrene.
A case of Fournier\'s gangrene requiring extensive debridement including bilateral orchiectomy and amputation of the penis.
Key words: Advanced carcinoma prostate, bilateral orchiectomy, flutamide.
The present study was done to evaluate the effects of combined androgen blockade in the treatment of advanced carcinoma prostate by bilateral orchiectomy with flutamide.
The principal diagnosis of prostate cancer appeared in approximately 90 percent of the hospitalizations for both white and black males who underwent bilateral orchiectomy (data not shown).
The average production rate of testosterone is 6 to 7 mg/day.[11] The usual peripheral serum concentration of testosterone is approximately 600 ng/dL, decreasing to 500 ng/dL after 70 years of age.[11] Bilateral orchiectomy reduces serum testosterone levels to an average of 43 [+ or -] 32 ng/dL.[2]
Bilateral orchiectomy promptly reduces androgen concentrations, with castration levels reached within 3 hours.[18] However, impotence is universal following this procedure, and the psychological trauma of castration should not be underestimated.[1] Indeed, it is important to note that given the choice, most patients (78%) will opt for equally effective medical alternatives to orchiectomy.[4] Such therapies include estrogens, LHRH analogs, and antiandrogens.
Hussain based her analysis on data collected from patients with de novo metastatic prostate cancer who were randomized in one trial to receive bilateral orchiectomy plus androgen-deprivation therapy or bilateral orchiectomy plus placebo, and patients in another randomized trial who tested continuous against intermittent androgen-deprivation therapy.
Other options for locally recurrent prostate cancer are observation or androgen ablation, which is achieved by leutinizing hormone--releasing hormone agonists, androgen blockade of target cells, or surgical castration via bilateral orchiectomy. The problem with androgen ablation, surgical or medical, is the burdensome side effects.
Bilateral orchiectomy, now an outpatient procedure, is effective immediately.
In their prospective study of men who had nodal metastases, 47 were randomly assigned to begin immediate antiandrogen therapy (either monthly goserelin injections or bilateral orchiectomy) and 51 to defer such treatment until there were signs of cancer progression.

Full browser ?