biguanides


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Related to biguanides: Sulfonylureas

biguanides

Drugs, such as METFORMIN and PHENFORMIN used to treat Type II DIABETES. They are part of the group of oral hypoglycaemic drugs. Biguanides act by reducing the efficiency of ION movement across cell membranes thus interfering with the production of glucose by the liver and reducing the energy yield from glucose used as fuel.
References in periodicals archive ?
Hirst, "Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase," BMC Biology, vol.
In previous calculations, the system recommended MET (Biguanides), DPP-4, SU (Sulfonylureas), and Insulin for patient_1.
The direct mechanistic knowledge on how biguanides (metformin, phenformin) influence mitochondrial function is not yet clear.
Metformin is a biguanide oral antidiabetic agent which is commonly used in the treatment of diabetes mellitus.
That led Shaw and his team to a class of drugs called biguanides, which lower cellular energy levels by attacking the power stations of the cell, called mitochondria.
The patents in suits cover a combination use of ACTOS with other oral antidiabetic products (?-glucosidase inhibitors, biguanides, and glimepiride), and Takeda believes that manufacturing and selling generic products of ACTOS without its consent will infringe such patents.
biguanides such as metformin in the prophylaxis (prevention) and/or therapy of
In the early 1970s, Professor Vladimir Dilman originally developed the idea that antidiabetic biguanides may be promising as geroprotectors and anticancer drugs ("metabolic rehabilitation").
Other classes of glucose-lowering drugs include sulfonylureas, meglitinides, biguanides, alpha-glucosidase inhibitors and dipeptyidyl peptidase-4 inhibitors.
Currently, there are six major classes of oral hypoglycemic agents available in the United States: agents that stimulate insulin secretion (sulfonylureas and rapid-acting secretagogues); reduce hepatic glucose production (biguanides); delay digestion and absorption of intestinal carbohydrates ([alpha]-glucosidase inhibitors); improve insulin action (thiazolidin-ediones [TZDs]); or inhibit glucagon release (dipeptidyl-peptidase 4 [DPP-4] inhibitors).