MAPK7

(redirected from Big MAP kinase 1)

MAPK7

A gene on chromosome 17p11.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK7 is activated by MAPK kinase 5—which is formed from MAPK2K5 and MEK5; it translocates to the nucleus, undergoes phosphorylation and regulates gene expression.
Mentioned in ?
References in periodicals archive ?
The mitogen-activated protein kinase (MAPK) cascades, consisting of the extracellular signal-related kinases (ERK1/2), the c-Jun N-terminal kinases (JNK), the p38 kinase (p38), and the big MAP kinase 1 (BMK1/ERK5) pathway [47], are major intracellular signal transduction pathways that play an important role in various cellular processes such as cell growth, differentiation, development, cell cycle, survival, and cell death [48].