bicuculline


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bi·cu·cul·line

(bī'kū-kyū'lēn),
An alkaloid naturally occurring in the d-form; found in Dicentra cucullaria and Adlumia fungosa (family Fumariaceae) and several Corydalis species; a powerful convulsant that acts by antagonizing γ-aminobutyric acid, an inhibitory neurotransmitter.

bicuculline

A photosensitive alkaloid first derived from Dicentra cucullaria, which is also found in Adlumia fungosa and herbs of genus Corydalis and Fumariaceae. It is a competitive antagonist of the neurotransmitter gamma-aminobutyric acid at the GABAA receptor, and has been used in model systems for epilepsy.
References in periodicals archive ?
Bicuculline infusions advance the timing of luteinizing hormone surge in proestrous rats: comparisons with naloxone effects.
Bicuculline insensitive GABA receptors: studies on the binding of (-)-baclofen to rat cerebellar membranes.
Identification of differential gene expression profiles in rat cortical cells exposed to the neuroactive agents trimethylolpropane phosphate and bicuculline.
In various experiments these included bicuculline, picrotoxin, Ro15-1788 (flumazenil) and delta-amino-n-valeric acid (Leslie, Shephard, & Toal, 1994; Shephard, Toal, & Leslie, 1990; Toal, Leslie, & Shephard, 1991).
Bicuculline (BIC) is a selective antagonist of GABA[sub]A R, which can inhibit the influence of chloride ions.
Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded under voltage-clamp at -70 mV from CA1 pyramidal neurons after blocking the GABAA receptors by using 30 [micro]M bicuculline.
A] antagonist, bicuculline methiodide (BMI, 100, 200 pmol/100 nl; n=24 rats, injections=47; Sigma)
Antagonism of [gamma]-aminobutyric acid (GABA) receptors with bicuculline (BIC) phenocopied the dendrite-promoting effects of PCB-95, and pharmacological antagonism or siRNA knockdown of RyR blocked BIC-induced dendritic growth in dissociated and slice cultures of hippocampal neurons.
Bicuculline was aliquoted in distilled water and diluted (1000-fold) in Ringer's to 10 [micro]M
Moreover, seizures induce IL-1 (3 release in cortex and hippocampus in bicuculline rat model and further cause blood-brain barrier damage with protein extravasation (Li et al.
A] antagonist bicuculline or the chloride channel blocker picrotoxin, and potentiated by 100 [[micro]molar] pentobarbital or 10 [[micro]molar] diazepam.