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Nitro-activated aryl halides are precursors to biaryl compounds which constitute the cornerstone of pharmaceutical industry, either through the century old Ullmann coupling or the more recent C-H functionalization methods.
Structure-based Design of a New Class of Biaryl Florfenicol Antibiotics Session Day / Time: 9/13/2010 11:15:00 AM - 1:15:00 PM
Gram quantities of biaryl compounds have been synthesized by gradual scale up of vials' sizes, a proof that this method can be used to reduce industrial waste en route to sustainability.
Biaryl synthesis, an important tool in medicinal chemistry, has been achieved by various synthetic methods including Ullmann's coupling of chlorinated nitroaromatics.
We might want to change the system by engineering in some benefit to being able to produce biaryls, just to stack the deck a bit.