beta-lactamase

(redirected from Betalactamase)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to Betalactamase: ESBL

β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.
References in periodicals archive ?
Cefoxitin when combined with Oxacillin agar or E test will be helpful to determine the all MRSA strains including hyper production of betalactamase.
Mechanisms of resistance in Entrobacteriaceae towards betalactamase antibiotics.
Extended-spectrum betalactamases: frequency, risk factors and outcomes.
Frequency of extended spectrum betalactamase (ESBLs) producing Escherichia coli and Klebseilla pneumoniae isolated from urine in an Iranian 1000 bed tertiary care hospital.
Foi observada a resistencia a oxacilina em 18 (54,5%) isolados, porem, nenhuma amplificacao por PCR do gene mecA foi observada nos isolados, o que pode sugerir a perda do gene ou uma hiperproducao de betalactamase. Dentre os 33 isolados avaliados, 11 (33,3%) foram positivos para o gene blaZ.
In addition, similar results have been reported in different studies and it has been emphasized that betalactamase ring may cause variance (20-22).
Nosocomial outbreak of Klebsiella pneumonia producing SHV-5 extended-spectrum betalactamase, originating from contaminated ultrasonography coupling gel.
aureus itself, but when combined with NXL104 it is also at least as active as carbapenems and fourth-generation cephalosporins against Enterobacteriaceae producing derepressed AmpC betalactamase.
Author's correction--Novel carbapenem-hydrolyzing betalactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
(**)Despite sensitivity in vitro, all strains produced an inducible betalactamase.
Prevalence of biofilm and betalactamase producing Staphylococcus in nasal and throat isolates from healthy volunteers: A medical alert.
Aranda-Michel et al., "Fatal endocarditis due to extended spectrum betalactamase producing Klebsiella terrigena in a liver transplant recipient," Wiener Klinische Wochenschrift, vol.