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Related to Betalactam: ESBL


A class of broad-spectrum antibiotics that are structurally and pharmacologically related to the penicillins and cephalosporins.


(bā′tə-lăk′təm, bē′-)
1. A lactam composed of a four-membered ring, formed by intramolecular condensation of an amino acid in which the amino group is located at the beta position, or any compound containing this group.
2. A beta-lactam antibiotic.


(bā'tă lak'tam)
Class of broad-spectrum antibiotics structurally and pharmacologically related to penicillins and cephalosporins.
References in periodicals archive ?
Diagnosis of immediate reactions to betalactam antibiotics.
If they have recently been exposed to a particular class of antibiotics, continued or repeated use of that class of antibiotics is not recommended or in the case of a betalactam, an agent in that same class with a broader spectrum should be used.
However, this tendency in co-occurring keywords seemed to be more toward pharmaceutical aspects in relation to the microbes and infections they caused (spectrum betalactam, chloramphenicol therapy, third-generation cephalosporins), and more pathologically oriented in non-co-occurring keywords (serotype distribution, strains, antimicrobial susceptibility, plasmids).
Bacteremic pneumococcal infections in immunocompromised patients without AIDS: the impact of betalactam resistance on mortality.
Aztreonam is a monobactam antibiotic that contains a betalactam ring.
pneumoniae (PNSP), studies have demonstrated that at the individual level, previous use of betalactam antibiotics such as penicillin is an important risk factor (8-10).
The failure of betalactam antibiotics to penetrate intracellular sites and kill nonmultiplying dormant bacteria may explain the frequent relapses of melioidosis after treatment with these drugs (25).
Our results (not shown) indicate that In-t2 serves as a vehicle for the oxa-1 gene, extending betalactam resistance to ureidopenicillins, and of the aadA1 gene, conferring resistance to streptomycin and spectinomycin.
This therapeutic approach is contrary to current guidelines, which recommend using betalactam antibiotics as first-choice therapy and reserving macrolides only for patients allergic to betalactams.
The researchers found snippets of genetic material in bacteria from river sediments downstream of the treatment plant that confetted resistance not only to ciprofloxacin, a fluoroquinolone, but also to betalactams, aminoglycosides, sulfonamides, and other classes of antibiotics.