In addition, oral betahistine
48 mg will be tested in 16 patients under open-label conditions for reference.
Usually the first line of treatment for a patient with vertigo is anti-vertigo drugs such as betahistine
, but if the dizziness persists the next step is to move on to vestibular rehabilitation.
However, many treatment options are offered by clinicians; some of which include dietary modifications, medical management with diuretics, steroids or betahistine
, and surgeries, such as decompression of the endolymphatic sac .
I had betahistine
tablets initially and then over six weeks I had to have three steroid injections through my ear drum, but they didn't help.
Patients who received oral medical treatment for ISSNHL were administered 1 mg/kg methylprednisolone (Prednol 16 mg tb, Mustafa Nevzat Ilac Sanayi A.S.; Istanbul, Turkey) for two to three weeks with incremental dose reductions every three days; acyclovir 400 mg tb 3x1 (Asiviral tb, Terra Ilac ve Kimya Sanayi Ticaret A.S.; Istanbul, Turkey) for 7 to 10 days; betahistine
dihydrochloride 24 mg tb 2x1 (Betaserc tb, Abbott Laboratuvarlari Ithalat Ihracat Tic.
* Prescribe betahistine
only for patients with Meniere's disease and not for patients with other causes of dizziness and/or vertigo, (B)
At this early stage, the patient was diagnosed with lef-tear blast injury and received intravenous pharmacological treatment comprising Methylprednisolonum, Piracetamum, Vinpocetinum and Betahistine
. No significant hearing improvement was observed after 5 days.
In Europe, the most widely used drug to treat MD patients is betahistine
, a histamine-like molecule .
Vertigo can be treated with high doses of corticosteroids  associated to betahistine
, a strong antagonist of the histamine H3 receptor and a weak agonist of the histamine H1 receptor, that improves vascularization of the inner ear .
The control group was given 24 mg of betahistine
dihydrochloride everyday divided into three doses for a total of seven days.
M2 PHARMA-February 3, 2017-Auris Medical expands clinical development pipeline with intranasal betahistine