A gene on chromosome 4q12-q13 that encodes a platelet-derived growth factor of the CXC chemokine family, which is a potent chemoattractant and activator of neutrophils. PPBP drives various cellular processes, including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
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References in periodicals archive ?
Elevated platelet activation in patients with atopic dermatitis and psoriasis: Increased plasma levels of beta-thromboglobulin and platelet factor 4.
Beta-thromboglobulin and platelet factor 4 levels were comparable between the groups (p=0.497; p=0.507.)
Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo.
In a previous study by Saleh et al it was shown that mean platelet factor-4 and beta-thromboglobulin plasma concentrations were higher in maternal circulation with preterm labor compared with levels of term labor.18 In agreement with the suggestion of platelet activation in preterm labor a recent study showed that maternal plasma sCD40L levels were higher in preterm labor compared with the concentrations of term labor.6
In a study of 16 diabetic patients, high cholesterol and high beta-thromboglobulin levels, pantethine significantly reduced beta-thromboglobulin, triglycerides, total cholesterol and apo levels with 600 mg for three months and 1200 mg for six months (42).
Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus.
Beta-thromboglobulin is considered the most abundant platelet-specific protein associated with clotting.
During each of several visits, the healthy volunteers' blood levels of the marker protein, beta-thromboglobulin (beta-TG), averaged about 30 nanograms per milliliter -- except in two of the participants.