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Related to Beta-lactams: Tetracyclines, Macrolides, Fluoroquinolones


A class of broad-spectrum antibiotics that are structurally and pharmacologically related to the penicillins and cephalosporins.


(bā′tə-lăk′təm, bē′-)
1. A lactam composed of a four-membered ring, formed by intramolecular condensation of an amino acid in which the amino group is located at the beta position, or any compound containing this group.
2. A beta-lactam antibiotic.


(bā'tă lak'tam)
Class of broad-spectrum antibiotics structurally and pharmacologically related to penicillins and cephalosporins.
References in periodicals archive ?
ETX2514 restores the in vitroactivity of multiple beta-lactams against Gram-negative, multi-drug resistant pathogens.
General Hospital ruled out penicillin allergies in 47 of 50 adult inpatients, and successfully transitioned them from second-line antibiotics to less expensive and more effective beta-lactam options.
MRSA is vulnerable to beta-lactams when the bacterium's ability to make a building block for its cell wall is disabled.
Pullorum (1/1) isolated between 1987 and 1991 were susceptible to beta-lactams AMC, CTX, CAZ, FEP, ATM, ETP, CTF and to the non-beta-lactams ENR, TET, CHL, FFC and SXT.
8 ppb, this kit can be used to accurately detect even low levels of beta-lactams in milk, meat, tissue, fish, honey, urine, and plasma at or below their maximum residue limits.
It is a common structural element of the penicillins, their synthetic and semi-synthetic derivatives, and other related molecules that constitute the broad family of drugs called the beta-lactam antibiotics.
We recommend that beta-lactams should not be prescribed to any patient of any age with known STEC 0157 infection and that clinicians should consider the risk of HUS when prescribing beta-lactams to any patients with diarrhea that could be caused by STEC 0157," she said.
Treatment with cephalosporins is associated with subsequent infection with resistant Enterococcus and other beta-lactam - resistant organisms.
With regard to antimicrobial agents, beta-lactams and quinolones must diffuse through porin channels in the outer membrane of the gram negative cell wall, but aminoglycosides and colistin interact with lipopolysaccharide on the outside of the outer membrane changing the permeability of the membrane so that they can pass through the membrane.
The goal of a 3-log reduction was based off of previous studies done which showed that a 3-log reduction is the maximum level of CI inactivation that can be verified for some beta-lactams.
Fluoroquinolones have no benefit over beta-lactams for acute bacterial rhinosinusitis (ABRS).
In particular, they look at the enzymatic capabilities of micro-organisms to introduce chemical modifications that negate the biological activity of beta-lactams or aminoglycoside antibiotics.

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