beta-lactam antibiotics

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Related to beta-lactam antibiotics: beta-lactamase, Aminoglycosides

beta-lactam antibiotics

An important group of drugs that includes the penicillins and the cephalosporins. All have a 4-membered beta-lactam ring as part of the basic structure. Many organisms produce beta-lactamase enzymes that can destroy these antibiotics. This is a common cause of bacterial resistance to antibiotics. Certain molecules called BETA-LACTAM INHIBITORS, however, can bind to beta-lactamase enzymes and inactivate them.


a cyclic amide formed from aminocarboxylic acids by elimination of water; lactams are isomeric with lactims, which are enol forms of lactams.

β-lactam antibiotics
includes the penicillins, cephalosporins, carbapenems and penems. See also β-lactam ring (below).
β-lactam ring
an integral part of the formula of β-lactam antibiotics. Disruption of the ring by β-lactamase produced by some bacteria, e.g. Escherichia coli, Bacillus anthracis, destroys the antimicrobial activity of the compound.
References in periodicals archive ?
These positive topline results demonstrate the potential for SYN-004 to protect the gut microbiome from the damaging effects of certain IV beta-lactam antibiotics for the prevention of C.
The MaxSignal Beta-Lactam ELISA Test Kit was developed to ease these concerns and assure that food is free of beta-lactam antibiotic residues.
The best evidence right now is that for simple cellulitis (no purulence, abscess, or exudate), treatment with a beta-lactam antibiotic is the best option.
Continuous infusion of beta-lactam antibiotics in severe sepsis: A multicenter double-blind, randomized controlled trial.
The Enterome microbiome study, scheduled for completion in the second half of 2014, is expected to provide a better understanding of the harmful effects of beta-lactam antibiotics on the gut bacterial community.
NYSE MKT: SYN), a developer of novel anti-infective biologic and drug candidates targeting specific pathogens that cause serious infections and diseases, and Enterome Bioscience SA, a pioneer in the development of innovative disease management solutions based on a deep understanding of the gut microbiome, today announced that they have entered into an agreement to conduct metagenomic research on the effects of beta-lactam antibiotics on the gastrointestinal microflora (microbiome) of human patients.
Risk of emergence of Pseudomonas aeruginosa resistance to beta-lactam antibiotics in intensive care units.
Clindamycin with gentamicin is an acceptable alternative for women with significant allergies to beta-lactam antibiotics.
Neurotoxicity induced by beta-lactam antibiotics from bench to bedside.
Only penicillin and its relatives, a drug family known as beta-lactam antibiotics, significantly raised the transporter concentrations in this neural tissue, the scientists report in the Jan.
The need for drugs that combat resistance is urgent, Tulkens says, especially in a world in which resistance to beta-lactam antibiotics (the penicillin family) is as high as 80% among some pneumonia-causing microbes.
Penicillins, as well as other beta-lactam antibiotics such as cephalosporins, carbapenems, and monobactams, contain a beta-lactam ring (2).

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