lactam

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Related to Beta-lactam Ring: beta-lactamase

lac·tam

, lactim (lak'tam, lak'tim),
Contractions of "lactoneamine" and "lactoneimine," and applied to the tautomeric forms -NH-CO- and -N=C(OH)-, respectively, observed in many purines, pyrimidines, and other substances; the latter form accounts for the acidic properties of uric acid.

lac·tam

, lactim (lak'tam, -tim)
Contractions of "lactoneamine" and "lactoneimine," applied to the tautomeric forms -NH-CO- and -N=C(OH)-, respectively, observed in many purines, pyrimidines, and other substances.
References in periodicals archive ?
The AY-lactam antibiotics are inactivated by Beta-lactamases that hydrolyze the amide bond that exists in the beta-lactam ring, disrupting the ring structure and make the antibiotics nonfunctional against bacteria.NDM-1 is a broad-spectrum AY-lactamasewhich has the ability to inactivate most of the AY- lactam antibiotics (Walsh et al., 2005).
Penicillinase is a specific type of [beta]-lactamase, showing specificity for penicillins, again by hydrolysing the beta-lactam ring. Molecular weights of the various penicillinases tend to cluster near 50kD (12-14).
Beta-lactamases are enzymes that cleave the beta-lactam ring, opening up the structure and destroying the ability of the beta-lactam to bind to its target.

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