hexosaminidase

(redirected from Beta-hexosaminidase)
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hex·os·a·min·i·dase

(hek'sōs-ă-min'i-dās),
General term for enzymes hydrolyzing N-acetylhexose (for example, N-acetylglucosamine) residues from gangliosidelike oligosaccharides. At least four specific enzymes carrying out this type of reaction are known: α-N-acetyl-d-galactosaminidase, α-N-acetyl-d-glucosaminidase, β-N-acetyl-d-hexosaminidase, and β-N-acetyl-d-galactosaminidase, each being specific for the configuration and type of sugar included in the name.

hexosaminidase

/hex·os·amin·i·dase/ (hek″sōs-ah-min´ĭ-dās)
1. any of the enzymes that cleave hexosamines or acetylated hexosamines from gangliosides or other glycosides.
2. a specific hexosaminidase acting on keratan sulfate and ganglioside GM2 and related compounds.

hex·os·a·min·i·dase

(heks-ōs'ă-min'i-dās)
General term for enzymes cleaving N-acetylhexose residues from gangliosidelike oligosaccharides.

hexosaminidase

an enzyme that catalyzes the cleavage of hexose from ganglioside GM2. Occurs in two forms, A and B. Deficiency occurs in GM2gangliosidosis of dogs, cats and pigs.
References in periodicals archive ?
Comparison of serum beta-hexosaminidase isoenzyme B activity with serum carbohydrate-deficient transferrin and other markers of alcohol abuse.
IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells.
Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells.
Increases and time-course variations in beta-hexosaminidase isoenzyme B and carbohydrate-deficient transferrin in serum from alcoholics are similar.
Both adult and infantile forms of the disease are caused by defects in an enzyme called beta-hexosaminidase.
found that extracts of Aceriphyllum rossii (native to Korea and China) and its active constituents, quercetin and kaempferol, blocked secretion of beta-hexosaminidase and histamine; lowered the production and mRNA expression of interleukin-4 and TNF-alpha; and reduced prostaglandin E2 and leukotriene B4 synthesis as well as the expression of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (J.

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