beta-galactosidase


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β-ga·lac·to·sid·ase

(gă-lak'tō-sīd'ās),
An enzyme that hydrolyzes the β-galactoside linkage in lactose-producing glucose and galactose; also hydrolyzes the chromogenic substrate IPTG (isopropylthiogalactoside) and thus is used as an indicator of fused genes and gene expression.

beta-galactosidase

See lactase.

GLB1

A gene on chromosome 3p21.33 that encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyses the terminal beta-galactose from gangliosides and other glycoconjugates.

Molecular biology
GLB1 mutations cause GM1-gangliosidosis and mucopolysaccharidosis IV (Morquio B syndrome).

β-galactosidase


β-galactosidase

a lysosome hydrolase.
References in periodicals archive ?
We found statistically significant correlations between increased resistance to 5-fluorocytosine and higher enzymatic activity of alpha-mannosidase; increased resistance to ketoconazole and higher enzymatic activity of trypsin; increased resistance to itraconazole and higher enzymatic activity of beta-glucosidase; increased resistance to fluconazole and higher enzymatic activity of beta-glucosidase; increased susceptibility to ketoconazole and higher enzymatic activity of beta-galactosidase and beta- glucosidase; increased susceptibility to itraconazole and higher enzymatic activity of valine arylamidase.
Of note, A[sz] did not induce the senescence-associated beta-galactosidase activity in cultured neurons (data not shown), indicating that SA-[sz]-gal was not required for neuronal senescence in vitro , although it was a classic CS biomarker.
Toussaint, "Protocols to detect senescence-associated beta-galactosidase (SA-[beta]gal) activity, a biomarker of senescent cells in culture and in vivo," Nature Protocols, vol.
Bone marrow transplantation correcting beta-galactosidase activity does not influence neurological outcome in juvenile [G.
The disorder is "caused by mutations in the GLB1 gene, which encodes an enzyme called beta-galactosidase necessary for recycling of a molecule (GM1-ganglioside) in neurons.
Regulation expression by readthrough translation from a plasmid-encoded beta-galactosidase.
It is an autosomal recessive sphingolipidosis caused by deficient activity of the lysosomal enzyme galactosylceramide beta-galactosidase (GALC) which degrades galactosylceramide, a main component of myelin, and other terminal beta-galactose-containing sphingolipids, including psychosine (galactosylsphingosine).
Quantitative examination of this interaction was calculated measuring Beta-galactosidase activity.
Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime.
Purification and characterization of an intracellular enzyme with beta-glucosidase and beta-galactosidase activity from the thermophilic fungus Talaromyces thermophilus CBS 236.