Dynamics of beta-cell mass in the growing rat pancreas: Estimation with a simple mathematical model.
Interventional strategies to prevent beta-cell apoptosis in islet transplantation.
Effects of different concentrations of glucose on proliferation, secretory function and apoptosis in mouse pancreatic beta-cell line NIT-1 (Chinese).
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
When Melton and his colleagues induced the livers of living mice to make more betatrophin, there was "a striking increase in beta-cell replication," an average of 17-fold higher than in control animals, the scientists wrote.
Betatrophin: A Hormone that Controls Pancreatic Beta-Cell Proliferation.
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function.
Habener, "If we can transplant beta-cells grown from a patient's own stem cells, the risk of rejection is gone, and now with the addition of GLP-1, we might be able to stimulate those cells to become truly functional in insulin production.
ViaCell has an exclusive worldwide license to three pending patents covering novel methodologies for the localization, isolation and transplantation of pancreatic stem cells that are capable of differentiating into insulin-producing beta-cells.
We conclude that suppression of endogenous insulin by intensive, continuous insulin treatment during the first two weeks after the diagnosis of (insulin-dependent diabetes melitus) may improve beta-cell
function during the subsequent year," the authors wrote.
They also secrete high amounts of insulin and C-peptide, making the cells an excellent research tool in the field of diabetes and for other beta cell-related studies, such as beta-cell
function, screening of compounds that regulate insulin secretion, GSIS studies, incretin response, pancreatitis research, and transdifferentiation studies.